4c12: Difference between revisions

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 ==X-ray Crystal Structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys and ADP==
-<StructureSection load='4c12' size='340' side='right' caption='[[4c12]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='4c12' size='340' side='right'caption='[[4c12]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4c12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C12 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4c12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C12 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UML:URIDINE+5DIPHOSPHO+N-ACETYL+MURAMOYL-L-ALANYL-D-GLUTAMYL-L-LYSINE'>UML</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UML:URIDINE+5DIPHOSPHO+N-ACETYL+MURAMOYL-L-ALANYL-D-GLUTAMYL-L-LYSINE'>UML</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c13|4c13]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c12 OCA], [https://pdbe.org/4c12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c12 RCSB], [https://www.ebi.ac.uk/pdbsum/4c12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c12 ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine_ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.7 6.3.2.7] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c12 OCA], [http://pdbe.org/4c12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c12 RCSB], [http://www.ebi.ac.uk/pdbsum/4c12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c12 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/MURE_STAA8 MURE_STAA8]] Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Can not use diaminopimelate as substrate. Seems to have a role in beta-lactam antibiotic resistance.<ref>PMID:14114846</ref> <ref>PMID:10498701</ref> <ref>PMID:14996801</ref>
+[https://www.uniprot.org/uniprot/MURE_STAA8 MURE_STAA8] Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Can not use diaminopimelate as substrate. Seems to have a role in beta-lactam antibiotic resistance.<ref>PMID:14114846</ref> <ref>PMID:10498701</ref> <ref>PMID:14996801</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 19: @@
 </div>
 <div class="pdbe-citations 4c12" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Mur ligase|Mur ligase]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase]]
+[[Category: Large Structures]]
-[[Category: Barreteau, H]]
+[[Category: Staphylococcus aureus]]
-[[Category: Blanot, D]]
+[[Category: Barreteau H]]
-[[Category: Boniface, A]]
+[[Category: Blanot D]]
-[[Category: Dementin, S]]
+[[Category: Boniface A]]
-[[Category: Dessen, A]]
+[[Category: Dementin S]]
-[[Category: Dowson, C G]]
+[[Category: Dessen A]]
-[[Category: Fulop, V]]
+[[Category: Dowson CG]]
-[[Category: Gobec, S]]
+[[Category: Fulop V]]
-[[Category: Lloyd, A J]]
+[[Category: Gobec S]]
-[[Category: Mengin-Lecreulx, D]]
+[[Category: Lloyd AJ]]
-[[Category: Roper, D I]]
+[[Category: Mengin-Lecreulx D]]
-[[Category: Ruane, K M]]
+[[Category: Roper DI]]
-[[Category: Ligase]]
+[[Category: Ruane KM]]