4bwl: Difference between revisions
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==Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid== | ==Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid== | ||
<StructureSection load='4bwl' size='340' side='right' caption='[[4bwl]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4bwl' size='340' side='right'caption='[[4bwl]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bwl]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4bwl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWL FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene>, <scene name='pdbligand=MN9:2-(ACETYLAMINO)-2-DEOXY-D-MANNOSE'>MN9</scene>, <scene name='pdbligand=SI3:5-(ACETYLAMINO)-3,5-DIDEOXY-D-GLYCERO-D-GALACTO-NON-2-ULOSONIC+ACID'>SI3</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwl OCA], [https://pdbe.org/4bwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bwl RCSB], [https://www.ebi.ac.uk/pdbsum/4bwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwl ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NANA_ECOLI NANA_ECOLI] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 21: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 4bwl" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4bwl" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Berry | [[Category: Berry A]] | ||
[[Category: Campeotto | [[Category: Campeotto I]] | ||
[[Category: Nelson | [[Category: Nelson A]] | ||
[[Category: Pearson | [[Category: Pearson AR]] | ||
[[Category: Phillips | [[Category: Phillips SEV]] | ||