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==Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.==
==Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.==
<StructureSection load='4bqs' size='340' side='right' caption='[[4bqs]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='4bqs' size='340' side='right'caption='[[4bqs]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bqs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bqs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=K2Q:(1R,6R,10S)-6,10-DIHYDROXY-2-OXABICYCLO[4.3.1]DECA-4(Z),7-DIENE-8-CARBOXYLIC+ACID'>K2Q</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=K2Q:(1R,6R,10S)-6,10-DIHYDROXY-2-OXABICYCLO[4.3.1]DECA-4(Z),7-DIENE-8-CARBOXYLIC+ACID'>K2Q</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bqs RCSB], [http://www.ebi.ac.uk/pdbsum/4bqs PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqs OCA], [https://pdbe.org/4bqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqs RCSB], [https://www.ebi.ac.uk/pdbsum/4bqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>
[https://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4bqs" style="background-color:#fffaf0;"></div>
==See Also==
*[[Shikimate kinase 3D structures|Shikimate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Shikimate kinase]]
[[Category: Blanco B]]
[[Category: Blanco, B]]
[[Category: Garcia-Doval C]]
[[Category: Garcia-Doval, C]]
[[Category: Gonzalez-Bello C]]
[[Category: Gonzalez-Bello, C]]
[[Category: Hawkins AR]]
[[Category: Hawkins, A R]]
[[Category: Lamb H]]
[[Category: Lamb, H]]
[[Category: Lence E]]
[[Category: Lence, E]]
[[Category: Llamas-Saiz AL]]
[[Category: Llamas-Saiz, A L]]
[[Category: Otero JM]]
[[Category: Otero, J M]]
[[Category: Prado V]]
[[Category: Prado, V]]
[[Category: Van Raaij MJ]]
[[Category: VanRaaij, M J]]
[[Category: Inhibitor]]
[[Category: Shikimic acid pathway]]
[[Category: Transferase]]

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