4bhb: Difference between revisions
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==Crystal structure of Mycobacterium tuberculosis O6-METHYLGUANINE METHYLTRANSFERASE== | ==Crystal structure of Mycobacterium tuberculosis O6-METHYLGUANINE METHYLTRANSFERASE== | ||
<StructureSection load='4bhb' size='340' side='right' caption='[[4bhb]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4bhb' size='340' side='right'caption='[[4bhb]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bhb]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4bhb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BHB FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhb OCA], [https://pdbe.org/4bhb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bhb RCSB], [https://www.ebi.ac.uk/pdbsum/4bhb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhb ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/OGT_MYCTU OGT_MYCTU] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[DNA methyltransferase|DNA methyltransferase]] | *[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Casazza | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Ciaramella | [[Category: Casazza V]] | ||
[[Category: Garavaglia | [[Category: Ciaramella M]] | ||
[[Category: Miggiano | [[Category: Garavaglia S]] | ||
[[Category: Perugino | [[Category: Miggiano R]] | ||
[[Category: Rizzii | [[Category: Perugino G]] | ||
[[Category: Rossi | [[Category: Rizzii M]] | ||
[[Category: Rossi F]] | |||