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==Crystal structure of Mycobacterium tuberculosis PanK in complex with a triazole inhibitory compound (1d) and phosphate==
==Crystal structure of Mycobacterium tuberculosis PanK in complex with a triazole inhibitory compound (1d) and phosphate==
<StructureSection load='4bfv' size='340' side='right' caption='[[4bfv]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='4bfv' size='340' side='right'caption='[[4bfv]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bfv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFV FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bfv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZVV:N-[1-(4-METHYL-5-{[2-(2-METHYLPHENOXY)ETHYL]SULFANYL}-4H-1,2,4-TRIAZOL-3-YL)ETHYL]-2-(TRIFLUOROMETHYL)BENZAMIDE'>ZVV</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bfs|4bfs]], [[4bft|4bft]], [[4bfu|4bfu]], [[4bfw|4bfw]], [[4bfx|4bfx]], [[4bfy|4bfy]], [[4bfz|4bfz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZVV:N-[1-(4-METHYL-5-{[2-(2-METHYLPHENOXY)ETHYL]SULFANYL}-4H-1,2,4-TRIAZOL-3-YL)ETHYL]-2-(TRIFLUOROMETHYL)BENZAMIDE'>ZVV</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfv OCA], [https://pdbe.org/4bfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfv RCSB], [https://www.ebi.ac.uk/pdbsum/4bfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfv RCSB], [http://www.ebi.ac.uk/pdbsum/4bfv PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COAA_MYCTU COAA_MYCTU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4bfv" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Pantothenate kinase|Pantothenate kinase]]
*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycobacterium tuberculosis h37rv]]
[[Category: Large Structures]]
[[Category: Pantothenate kinase]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Bergfors, T]]
[[Category: Bergfors T]]
[[Category: Bjorkelid, C]]
[[Category: Bjorkelid C]]
[[Category: Jones, T A]]
[[Category: Jones TA]]
[[Category: Coa pathway]]
[[Category: Inhibitor]]
[[Category: Transferase]]

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