4b9x: Difference between revisions

<StructureSection load='4b9x' size='340' side='right'caption='[[4b9x]], [[Resolution|resolution]] 2.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[4b9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B9X FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9x OCA], [https://pdbe.org/4b9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b9x RCSB], [https://www.ebi.ac.uk/pdbsum/4b9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9x ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TDRD1_MOUSE TDRD1_MOUSE] Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.<ref>PMID:17038506</ref> <ref>PMID:19465913</ref> <ref>PMID:19584108</ref>  

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Cusack S]]

[[Category: Kadlec J]]

[[Category: Mathioudakis N]]

[[Category: Palencia A]]

[[Category: Pillai RS]]

[[Category: Round A]]

[[Category: Sattler M]]

[[Category: Tripsianes K]]