4azy: Difference between revisions
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==Design and Synthesis of BACE1 Inhibitors with In Vivo Brain Reduction of beta-Amyloid Peptides (COMPOUND 10)== | ==Design and Synthesis of BACE1 Inhibitors with In Vivo Brain Reduction of beta-Amyloid Peptides (COMPOUND 10)== | ||
<StructureSection load='4azy' size='340' side='right' caption='[[4azy]], [[Resolution|resolution]] 1.79Å' scene=''> | <StructureSection load='4azy' size='340' side='right'caption='[[4azy]], [[Resolution|resolution]] 1.79Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4azy]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4azy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AZY FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7F3:(1S)-4-FLUORO-1-(4-FLUORO-3-PYRIMIDIN-5-YLPHENYL)-1-[2-(TRIFLUOROMETHYL)PYRIDIN-4-YL]-1H-ISOINDOL-3-AMINE'>7F3</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7F3:(1S)-4-FLUORO-1-(4-FLUORO-3-PYRIMIDIN-5-YLPHENYL)-1-[2-(TRIFLUOROMETHYL)PYRIDIN-4-YL]-1H-ISOINDOL-3-AMINE'>7F3</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4azy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4azy OCA], [https://pdbe.org/4azy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4azy RCSB], [https://www.ebi.ac.uk/pdbsum/4azy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4azy ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4azy" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Beta secretase|Beta secretase]] | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Andersson | [[Category: Andersson L]] | ||
[[Category: Berg | [[Category: Berg S]] | ||
[[Category: Bergh | [[Category: Bergh M]] | ||
[[Category: Bogar | [[Category: Bogar K]] | ||
[[Category: Eketjall | [[Category: Eketjall S]] | ||
[[Category: Falting | [[Category: Falting J]] | ||
[[Category: Georgievska | [[Category: Georgievska B]] | ||
[[Category: Holenz | [[Category: Holenz J]] | ||
[[Category: Janson | [[Category: Janson J]] | ||
[[Category: Jeppsson | [[Category: Jeppsson F]] | ||
[[Category: Karlstrom | [[Category: Karlstrom S]] | ||
[[Category: Kers | [[Category: Kers A]] | ||
[[Category: Kihlstrom | [[Category: Kihlstrom J]] | ||
[[Category: Kolmodin | [[Category: Kolmodin K]] | ||
[[Category: Lindstrom | [[Category: Lindstrom J]] | ||
[[Category: Ohberg | [[Category: Ohberg L]] | ||
[[Category: Olsson | [[Category: Olsson LL]] | ||
[[Category: Pyring | [[Category: Pyring D]] | ||
[[Category: Slivo | [[Category: Slivo C]] | ||
[[Category: Soderman | [[Category: Soderman P]] | ||
[[Category: Sundstrom | [[Category: Sundstrom M]] | ||
[[Category: Swahn | [[Category: Swahn BM]] | ||
[[Category: Turek | [[Category: Turek D]] | ||
[[Category: | [[Category: Von Berg S]] | ||