4azq: Difference between revisions
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<StructureSection load='4azq' size='340' side='right'caption='[[4azq]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4azq' size='340' side='right'caption='[[4azq]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4azq]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4azq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AZQ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G2A:2-HYDROXY-1-(HYDROXYMETHYL)ETHYL+ICOSANOATE'>G2A</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G2A:2-HYDROXY-1-(HYDROXYMETHYL)ETHYL+ICOSANOATE'>G2A</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4azq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4azq OCA], [https://pdbe.org/4azq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4azq RCSB], [https://www.ebi.ac.uk/pdbsum/4azq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4azq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FABP5_MOUSE FABP5_MOUSE] High specificity for fatty acids. Highest affinity for C18 chain length (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Deutsch | [[Category: Deutsch D]] | ||
[[Category: Kaczocha | [[Category: Kaczocha M]] | ||
[[Category: Li | [[Category: Li H]] | ||
[[Category: Ojima | [[Category: Ojima I]] | ||
[[Category: Sanson | [[Category: Sanson B]] | ||
[[Category: Sun | [[Category: Sun J]] | ||
[[Category: Wang | [[Category: Wang T]] | ||
Latest revision as of 14:39, 20 December 2023
Murine epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid 2-arachidonoylglycerolMurine epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid 2-arachidonoylglycerol
Structural highlights
FunctionFABP5_MOUSE High specificity for fatty acids. Highest affinity for C18 chain length (By similarity). Publication Abstract from PubMedIn addition to binding intracellular fatty acids, fatty-acid-binding proteins (FABPs) have recently been reported to also transport the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), arachidonic acid derivatives that function as neurotransmitters and mediate a diverse set of physiological and psychological processes. To understand how the endocannabinoids bind to FABPs, the crystal structures of FABP5 in complex with AEA, 2-AG and the inhibitor BMS-309403 were determined. These ligands are shown to interact primarily with the substrate-binding pocket via hydrophobic interactions as well as a common hydrogen bond to the Tyr131 residue. This work advances our understanding of FABP5-endocannabinoid interactions and may be useful for future efforts in the development of small-molecule inhibitors to raise endocannabinoid levels. Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.,Sanson B, Wang T, Sun J, Wang L, Kaczocha M, Ojima I, Deutsch D, Li H Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):290-8. doi:, 10.1107/S1399004713026795. Epub 2014 Jan 29. PMID:24531463[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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