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==Crystal structure of autoreactive-Valpha14-Vbeta6 NKT TCR in complex with CD1d-sulfatide==
==Crystal structure of autoreactive-Valpha14-Vbeta6 NKT TCR in complex with CD1d-sulfatide==
<StructureSection load='4apq' size='340' side='right' caption='[[4apq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4apq' size='340' side='right'caption='[[4apq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4apq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4apq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CIS:(15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE'>CIS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bii|1bii]], [[1bqh|1bqh]], [[1bz9|1bz9]], [[1cd1|1cd1]], [[1ddh|1ddh]], [[1ffn|1ffn]], [[1ffo|1ffo]], [[1ffp|1ffp]], [[1fg2|1fg2]], [[1fo0|1fo0]], [[1fzj|1fzj]], [[1fzk|1fzk]], [[1fzm|1fzm]], [[1fzo|1fzo]], [[1g6r|1g6r]], [[1g7p|1g7p]], [[1g7q|1g7q]], [[1hoc|1hoc]], [[1inq|1inq]], [[1jpf|1jpf]], [[1jpg|1jpg]], [[1juf|1juf]], [[1k8d|1k8d]], [[1kbg|1kbg]], [[1kj2|1kj2]], [[1kj3|1kj3]], [[1kpu|1kpu]], [[1kpv|1kpv]], [[1l6q|1l6q]], [[1ld9|1ld9]], [[1ldp|1ldp]], [[1leg|1leg]], [[1lek|1lek]], [[1lk2|1lk2]], [[1mhc|1mhc]], [[1mwa|1mwa]], [[1n3n|1n3n]], [[1n59|1n59]], [[1n5a|1n5a]], [[1nam|1nam]], [[1nan|1nan]], [[1nez|1nez]], [[1osz|1osz]], [[1p1z|1p1z]], [[1p4l|1p4l]], [[1pqz|1pqz]], [[1qo3|1qo3]], [[1rjy|1rjy]], [[1rjz|1rjz]], [[1rk0|1rk0]], [[1rk1|1rk1]], [[1s7q|1s7q]], [[1s7r|1s7r]], [[1s7s|1s7s]], [[1s7t|1s7t]], [[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[1t0m|1t0m]], [[1t0n|1t0n]], [[1u58|1u58]], [[1vac|1vac]], [[1vad|1vad]], [[1wbx|1wbx]], [[1wby|1wby]], [[1wbz|1wbz]], [[1yn6|1yn6]], [[1yn7|1yn7]], [[1z5l|1z5l]], [[1zhb|1zhb]], [[1zhn|1zhn]], [[1zt1|1zt1]], [[1zt7|1zt7]], [[2akr|2akr]], [[2ckb|2ckb]], [[2clv|2clv]], [[2clz|2clz]], [[2fik|2fik]], [[2fwo|2fwo]], [[2mha|2mha]], [[2vaa|2vaa]], [[2vab|2vab]], [[2ve6|2ve6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CIS:(15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE'>CIS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4apq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4apq RCSB], [http://www.ebi.ac.uk/pdbsum/4apq PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apq OCA], [https://pdbe.org/4apq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apq RCSB], [https://www.ebi.ac.uk/pdbsum/4apq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref>


==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[CD1|CD1]]
*[[CD1|CD1]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Clarke, A J]]
[[Category: Clarke AJ]]
[[Category: Nours, J Le]]
[[Category: Le Nours J]]
[[Category: Rossjohn, J]]
[[Category: Rossjohn J]]
[[Category: Apc cell surface]]
[[Category: Immune system]]
[[Category: Immunity]]

Latest revision as of 14:32, 20 December 2023

Crystal structure of autoreactive-Valpha14-Vbeta6 NKT TCR in complex with CD1d-sulfatideCrystal structure of autoreactive-Valpha14-Vbeta6 NKT TCR in complex with CD1d-sulfatide

Structural highlights

4apq is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CD1D1_MOUSE Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3]

See Also

References

  1. ↑ Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec;15(6):897-908. PMID:11754812
  2. ↑ Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 doi:10.1084/jem.20051625
  3. ↑ Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 doi:10.1038/ni1224

4apq, resolution 3.00Å

Drag the structure with the mouse to rotate

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