4apo: Difference between revisions

<StructureSection load='4apo' size='340' side='right' caption='[[4apo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[4apo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APO FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4aif|4aif]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4apo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4apo RCSB], [http://www.ebi.ac.uk/pdbsum/4apo PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/AIP_HUMAN AIP_HUMAN]] Acromegaly;Familial prolactinoma. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA) [MIM:[http://omim.org/entry/102200 102200]]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma.<ref>PMID:17244780</ref> <ref>PMID:17299063</ref> <ref>PMID:17360484</ref> <ref>PMID:18410548</ref>  Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA) [MIM:[http://omim.org/entry/219090 219090]]; also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.  Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA) [MIM:[http://omim.org/entry/600634 600634]]; also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.  

[[http://www.uniprot.org/uniprot/AIP_HUMAN AIP_HUMAN]] May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.  Cellular negative regulator of the hepatitis B virus (HBV) X protein.  

[[Category: Morgan, R M.L]]

[[Category: Pearl, L H]]

[[Category: Prodromou, C]]

[[Category: Roe, S M]]

[[Category: Aryl hydrocarbon receptor]]

[[Category: Signaling protein-peptide complex]]