4al6: Difference between revisions

<StructureSection load='4al6' size='340' side='right'caption='[[4al6]], [[Resolution|resolution]] 2.63&Aring;' scene=''>

<table><tr><td colspan='2'>[[4al6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_UCBPP-PA14 Pseudomonas aeruginosa UCBPP-PA14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AL6 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4al6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4al6 OCA], [https://pdbe.org/4al6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4al6 RCSB], [https://www.ebi.ac.uk/pdbsum/4al6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4al6 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/CAS6_PSEAB CAS6_PSEAB] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units. Absolutely required for crRNA production or stability. Upon expression in E.coli endonucleolytically processes pre-crRNA, although disruption and reconstitution experiments indicate that in situ other genes are also required for processing. Yields 5'-hydroxy and 3'-phosphate groups. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.<ref>PMID:20829488</ref> <ref>PMID:21398535</ref> <ref>PMID:22522703</ref>  

*[[Endonuclease 3D structures|Endonuclease 3D structures]]

[[Category: Large Structures]]

[[Category: Pseudomonas aeruginosa UCBPP-PA14]]

[[Category: Doudna JA]]

[[Category: Haurwitz RE]]

[[Category: Sternberg SH]]