4ai2: Difference between revisions
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The | ==Flo5A showing a heptanuclear gadolinium cluster on its surface after 41 min of soaking== | ||
<StructureSection load='4ai2' size='340' side='right'caption='[[4ai2]], [[Resolution|resolution]] 1.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ai2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AI2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ai2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ai2 OCA], [https://pdbe.org/4ai2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ai2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ai2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ai2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FLO5_YEAST FLO5_YEAST] Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Protein-bound contrast: The unusual observation of a heptanuclear gadolinium-oxo cluster on the surface of the cell-adhesion protein Flo5A establishes the basis for directed incorporation of poly-lanthanide clusters into biomolecules. The observed gadolinium cluster might serve as a paradigm for the design of protein-based MRI contrast agents. | |||
Complex Gadolinium-Oxo Clusters Formed along Concave Protein Surfaces.,Veelders M, Essen LO Chembiochem. 2012 Aug 31. doi: 10.1002/cbic.201200441. PMID:22936626<ref>PMID:22936626</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4ai2" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Flocculation protein 3D structures|Flocculation protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Essen L-O]] | |||
[[Category: Veelders M]] | |||
Latest revision as of 14:27, 20 December 2023
Flo5A showing a heptanuclear gadolinium cluster on its surface after 41 min of soakingFlo5A showing a heptanuclear gadolinium cluster on its surface after 41 min of soaking
Structural highlights
FunctionFLO5_YEAST Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. Publication Abstract from PubMedProtein-bound contrast: The unusual observation of a heptanuclear gadolinium-oxo cluster on the surface of the cell-adhesion protein Flo5A establishes the basis for directed incorporation of poly-lanthanide clusters into biomolecules. The observed gadolinium cluster might serve as a paradigm for the design of protein-based MRI contrast agents. Complex Gadolinium-Oxo Clusters Formed along Concave Protein Surfaces.,Veelders M, Essen LO Chembiochem. 2012 Aug 31. doi: 10.1002/cbic.201200441. PMID:22936626[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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