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==Crystal structure of cryptococcal inosine monophosphate dehydrogenase==
==Crystal structure of cryptococcal inosine monophosphate dehydrogenase==
<StructureSection load='4af0' size='340' side='right' caption='[[4af0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4af0' size='340' side='right'caption='[[4af0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4af0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crynh Crynh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AF0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AF0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4af0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans_var._grubii_H99 Cryptococcus neoformans var. grubii H99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AF0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4af0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4af0 OCA], [http://pdbe.org/4af0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4af0 RCSB], [http://www.ebi.ac.uk/pdbsum/4af0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4af0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4af0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4af0 OCA], [https://pdbe.org/4af0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4af0 RCSB], [https://www.ebi.ac.uk/pdbsum/4af0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4af0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/E3P6S0_CRYNE E3P6S0_CRYNE]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_03156]  
[https://www.uniprot.org/uniprot/E3P6S0_CRYNE E3P6S0_CRYNE] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_03156]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]]
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Crynh]]
[[Category: Cryptococcus neoformans var. grubii H99]]
[[Category: IMP dehydrogenase]]
[[Category: Large Structures]]
[[Category: Fraser, J A]]
[[Category: Fraser JA]]
[[Category: Kobe, B]]
[[Category: Kobe B]]
[[Category: Morrow, C A]]
[[Category: Morrow CA]]
[[Category: Stamp, A]]
[[Category: Stamp A]]
[[Category: Valkov, E]]
[[Category: Valkov E]]
[[Category: Drug resistance]]
[[Category: Gtp biosynthesis]]
[[Category: Oxidoreductase]]

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