4ael: Difference between revisions

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-'''Unreleased structure'''
-The entry 4ael is ON HOLD
+==PDE10A in complex with the inhibitor AZ5==
+<StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEL FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [https://pdbe.org/4ael PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [https://www.ebi.ac.uk/pdbsum/4ael PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A series of 1,6-naphthyridine-based compounds was synthesized as potent phosphodiesterase 10A (PDE10A) inhibitors. Structure-based chemical modifications of the discovered chemotype served to further improve potency and selectivity over DHODH, laying the foundation for future optimization efforts.
-Authors: Bauer, U., Giordanetto, F., Bauer, M., OMahony, G., Johansson, K.E., Knecht, W., Hartleib-Geschwindner, J., Toppner Carlsson, E., Enroth, C., Sjogren, T.
+Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors.,Bauer U, Giordanetto F, Bauer M, O'Mahony G, Johansson KE, Knecht W, Hartleib-Geschwindner J, Carlsson ET, Enroth C Bioorg Med Chem Lett. 2012 Mar 1;22(5):1944-8. Epub 2012 Jan 26. PMID:22321214<ref>PMID:22321214</ref>
-Description: PDE10A in complex with the inhibitor AZ5
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4ael" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bauer M]]
+[[Category: Bauer U]]
+[[Category: Enroth C]]
+[[Category: Giordanetto F]]
+[[Category: Hartleib-Geschwindner J]]
+[[Category: Johansson KE]]
+[[Category: Knecht W]]
+[[Category: OMahony G]]
+[[Category: Sjogren T]]
+[[Category: Toppner Carlsson E]]