4a2q: Difference between revisions

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-[[Image:4a2q.png|left|200px]]
-<!--
+==Structure of duck RIG-I tandem CARDs and helicase domain==
-The line below this paragraph, containing "STRUCTURE_4a2q", creates the "Structure Box" on the page.
+<StructureSection load='4a2q' size='340' side='right'caption='[[4a2q]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[4a2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A2Q FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2q OCA], [https://pdbe.org/4a2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a2q RCSB], [https://www.ebi.ac.uk/pdbsum/4a2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2q ProSAT]</span></td></tr>
-{{STRUCTURE_4a2q|  PDB=4a2q  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/D3TI84_ANAPL D3TI84_ANAPL]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+RIG-I is a key innate immune pattern-recognition receptor that triggers interferon expression upon detection of intracellular 5'triphosphate double-stranded RNA (5'ppp-dsRNA) of viral origin. RIG-I comprises N-terminal caspase activation and recruitment domains (CARDs), a DECH helicase, and a C-terminal domain (CTD). We present crystal structures of the ligand-free, autorepressed, and RNA-bound, activated states of RIG-I. Inactive RIG-I has an open conformation with the CARDs sequestered by a helical domain inserted between the two helicase moieties. ATP and dsRNA binding induce a major rearrangement to a closed conformation in which the helicase and CTD bind the blunt end 5'ppp-dsRNA with perfect complementarity but incompatibly with continued CARD binding. We propose that after initial binding of 5'ppp-dsRNA to the flexibly linked CTD, co-operative tight binding of ATP and RNA to the helicase domain liberates the CARDs for downstream signaling. These findings significantly advance our molecular understanding of the activation of innate immune signaling helicases.
-===STRUCTURE OF DUCK RIG-I TANDEM CARDS AND HELICASE DOMAIN===
+Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA.,Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S Cell. 2011 Oct 14;147(2):423-35. PMID:22000019<ref>PMID:22000019</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_22000019}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 4a2q" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 22000019 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_22000019}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[4a2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2Q OCA].
-==Reference==
-<ref group="xtra">PMID:022000019</ref><references group="xtra"/>
 [[Category: Anas platyrhynchos]]
-[[Category: Cusack, S.]]
+[[Category: Large Structures]]
-[[Category: Kowalinski, E.]]
+[[Category: Cusack S]]
-[[Category: Lunardi, T.]]
+[[Category: Kowalinski E]]
-[[Category: Mccarthy, A A.]]
+[[Category: Lunardi T]]
-[[Category: Antiviral signalling pathway]]
+[[Category: McCarthy AA]]
-[[Category: Atp and dsrna binding]]
-[[Category: Hydrolase]]
-[[Category: Superfamily 2 rna helicase]]