4a1o: Difference between revisions

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-==CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PURH COMPLEXED WITH AICAR AND A NOVEL NUCLEOTIDE CFAIR, AT 2.48 A RESOLUTION.==
-<StructureSection load='4a1o' size='340' side='right' caption='[[4a1o]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
+==Crystal structure of Mycobacterium tuberculosis PurH complexed with AICAR and a novel nucleotide CFAIR, at 2.48 A resolution.==
+<StructureSection load='4a1o' size='340' side='right'caption='[[4a1o]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4a1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A1O FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4a1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A1O FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=JLN:5-(FORMYLAMINO)-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC+ACID'>JLN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zzm|3zzm]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=JLN:5-(FORMYLAMINO)-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC+ACID'>JLN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a1o RCSB], [http://www.ebi.ac.uk/pdbsum/4a1o PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1o OCA], [https://pdbe.org/4a1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a1o RCSB], [https://www.ebi.ac.uk/pdbsum/4a1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a1o ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PUR9_MYCTU PUR9_MYCTU]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 13: / Line 16: @@
 Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.,Le Nours J, Bulloch EM, Zhang Z, Greenwood DR, Middleditch MJ, Dickson JM, Baker EN J Biol Chem. 2011 Sep 28. PMID:21956117<ref>PMID:21956117</ref>
-From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4a1o" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Bifunctional purine biosynthesis protein PURH|Bifunctional purine biosynthesis protein PURH]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Mycobacterium tuberculosis]]
+[[Category: Large Structures]]
-[[Category: Baker, E N.]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-[[Category: Bulloch, E M.M.]]
+[[Category: Baker EN]]
-[[Category: Dickson, J M.J.]]
+[[Category: Bulloch EMM]]
-[[Category: Greenwood, D R.]]
+[[Category: Dickson JMJ]]
-[[Category: Middleditch, M J.]]
+[[Category: Greenwood DR]]
-[[Category: Nours, J Le.]]
+[[Category: Le Nours J]]
-[[Category: Zhang, Z.]]
+[[Category: Middleditch MJ]]
-[[Category: Transferase-hydrolase]]
+[[Category: Zhang Z]]