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==Human Mitochondrial endo-exonuclease==
==Human Mitochondrial endo-exonuclease==
<StructureSection load='4a1n' size='340' side='right' caption='[[4a1n]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4a1n' size='340' side='right'caption='[[4a1n]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4a1n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A1N FirstGlance]. <br>
<table><tr><td colspan='2'>[[4a1n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A1N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1n OCA], [http://pdbe.org/4a1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a1n RCSB], [http://www.ebi.ac.uk/pdbsum/4a1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a1n ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1n OCA], [https://pdbe.org/4a1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a1n RCSB], [https://www.ebi.ac.uk/pdbsum/4a1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a1n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/EXOG_HUMAN EXOG_HUMAN]] Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.<ref>PMID:18187503</ref>
[https://www.uniprot.org/uniprot/EXOG_HUMAN EXOG_HUMAN] Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.<ref>PMID:18187503</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Berglund, H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Berglund H]]
[[Category: Collins, R]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Collins R]]
[[Category: Flodin, S]]
[[Category: Edwards AM]]
[[Category: Graslund, S]]
[[Category: Flodin S]]
[[Category: Hammarstrom, M]]
[[Category: Graslund S]]
[[Category: Johansson, I]]
[[Category: Hammarstrom M]]
[[Category: Karlberg, T]]
[[Category: Johansson I]]
[[Category: Kotenyova, T]]
[[Category: Karlberg T]]
[[Category: Moche, M]]
[[Category: Kotenyova T]]
[[Category: Nordlund, P]]
[[Category: Moche M]]
[[Category: Nyman, T]]
[[Category: Nordlund P]]
[[Category: Persson, C]]
[[Category: Nyman T]]
[[Category: Schuler, H]]
[[Category: Persson C]]
[[Category: Thorsell, A G]]
[[Category: Schuler H]]
[[Category: Tresaugues, L]]
[[Category: Thorsell AG]]
[[Category: Weigelt, J]]
[[Category: Tresaugues L]]
[[Category: Welin, M]]
[[Category: Weigelt J]]
[[Category: Hydrolase]]
[[Category: Welin M]]

Latest revision as of 14:18, 20 December 2023

Human Mitochondrial endo-exonucleaseHuman Mitochondrial endo-exonuclease

Structural highlights

4a1n is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EXOG_HUMAN Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.[1]

References

  1. ↑ Cymerman IA, Chung I, Beckmann BM, Bujnicki JM, Meiss G. EXOG, a novel paralog of Endonuclease G in higher eukaryotes. Nucleic Acids Res. 2008 Mar;36(4):1369-79. doi: 10.1093/nar/gkm1169. Epub 2008, Jan 10. PMID:18187503 doi:http://dx.doi.org/10.1093/nar/gkm1169

4a1n, resolution 2.80Å

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