3zpc: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Acinetobacter baumannii RibD, form 1==
==Acinetobacter baumannii RibD, form 1==
<StructureSection load='3zpc' size='340' side='right' caption='[[3zpc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3zpc' size='340' side='right'caption='[[3zpc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zpc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZPC FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zpc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZPC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zpg|3zpg]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpc OCA], [http://pdbe.org/3zpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zpc RCSB], [http://www.ebi.ac.uk/pdbsum/3zpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpc OCA], [https://pdbe.org/3zpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zpc RCSB], [https://www.ebi.ac.uk/pdbsum/3zpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/D0CB74_ACIBA D0CB74_ACIBA]] Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.[PIRNR:PIRNR006769]  
[https://www.uniprot.org/uniprot/D0CB74_ACIB2 D0CB74_ACIB2] Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.[ARBA:ARBA00002151][PIRNR:PIRNR006769]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aciba]]
[[Category: Acinetobacter baumannii]]
[[Category: Chrysostomou, G]]
[[Category: Large Structures]]
[[Category: Dawson, A]]
[[Category: Chrysostomou G]]
[[Category: Hunter, W N]]
[[Category: Dawson A]]
[[Category: Trumper, P]]
[[Category: Hunter WN]]
[[Category: Deaminase]]
[[Category: Trumper P]]
[[Category: Oxidoreductase]]
[[Category: Reductase]]

Latest revision as of 14:09, 20 December 2023

Acinetobacter baumannii RibD, form 1Acinetobacter baumannii RibD, form 1

Structural highlights

3zpc is a 2 chain structure with sequence from Acinetobacter baumannii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

D0CB74_ACIB2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.[ARBA:ARBA00002151][PIRNR:PIRNR006769]

Publication Abstract from PubMed

The bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase (RibD) represents a potential antibacterial drug target. The structure of recombinant Acinetobacter baumannii RibD is reported in orthorhombic and tetragonal crystal forms at 2.2 and 2.0 A resolution, respectively. Comparisons with orthologous structures in the Protein Data Bank indicated close similarities. The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine-binding site of the reductase domain.

Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii.,Dawson A, Trumper P, Chrysostomou G, Hunter WN Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):611-7. doi:, 10.1107/S174430911301292X. Epub 2013 May 23. PMID:23722836[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Dawson A, Trumper P, Chrysostomou G, Hunter WN. Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):611-7. doi:, 10.1107/S174430911301292X. Epub 2013 May 23. PMID:23722836 doi:10.1107/S174430911301292X

3zpc, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3zpc&oldid=3997142"