3zon: Difference between revisions
New page: '''Unreleased structure''' The entry 3zon is ON HOLD Authors: Elkins, J.M., Wang, J., Krojer, T., Savitsky, P., Chalk, R., Daga, N., Salah, E., Berridge, G., Picaud, S., von Delft, F., ... |
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==Human TYK2 pseudokinase domain bound to a kinase inhibitor== | |||
<StructureSection load='3zon' size='340' side='right'caption='[[3zon]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3zon]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZON FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IK1:5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE'>IK1</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zon OCA], [https://pdbe.org/3zon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zon RCSB], [https://www.ebi.ac.uk/pdbsum/3zon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zon ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> | |||
==See Also== | |||
*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Berridge G]] | |||
[[Category: Bountra C]] | |||
[[Category: Chalk R]] | |||
[[Category: Daga N]] | |||
[[Category: Edwards A]] | |||
[[Category: Elkins JM]] | |||
[[Category: Knapp S]] | |||
[[Category: Krojer T]] | |||
[[Category: Picaud S]] | |||
[[Category: Salah E]] | |||
[[Category: Savitsky P]] | |||
[[Category: Wang J]] | |||
[[Category: Von Delft F]] | |||