3zmz: Difference between revisions

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 ==LSD1-CoREST in complex with PRSFAV peptide==
-<StructureSection load='3zmz' size='340' side='right' caption='[[3zmz]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+<StructureSection load='3zmz' size='340' side='right'caption='[[3zmz]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3zmz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZMZ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3zmz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZMZ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zms|3zms]], [[3zmt|3zmt]], [[3zmu|3zmu]], [[3zmv|3zmv]], [[3zn0|3zn0]], [[3zn1|3zn1]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zmz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zmz RCSB], [http://www.ebi.ac.uk/pdbsum/3zmz PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zmz OCA], [https://pdbe.org/3zmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zmz RCSB], [https://www.ebi.ac.uk/pdbsum/3zmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zmz ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3zmz" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Lysine-specific histone demethylase 1|Lysine-specific histone demethylase 1]]
+*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
 == References ==
 <references/>
@@ Line 23: / Line 27: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Baron, R]]
+[[Category: Large Structures]]
-[[Category: Borrello, M T]]
+[[Category: Baron R]]
-[[Category: Chiarelli, L R]]
+[[Category: Borrello MT]]
-[[Category: Ciossani, G]]
+[[Category: Chiarelli LR]]
-[[Category: Connell, M O]]
+[[Category: Ciossani G]]
-[[Category: Cowan, J]]
+[[Category: Cowan J]]
-[[Category: Ganesan, A]]
+[[Category: Ganesan A]]
-[[Category: Mai, A]]
+[[Category: Mai A]]
-[[Category: Mattevi, A]]
+[[Category: Mattevi A]]
-[[Category: Pilotto, S]]
+[[Category: O'Connell M]]
-[[Category: Tardugno, M]]
+[[Category: Pilotto S]]
-[[Category: Tortorici, M]]
+[[Category: Tardugno M]]
-[[Category: Vellore, N A]]
+[[Category: Tortorici M]]
-[[Category: Chromatin]]
+[[Category: Vellore NA]]
-[[Category: Demethylase]]
-[[Category: Oxidoreductase]]
-[[Category: Transcription factor]]