3zln: Difference between revisions

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 ==Crystal structure of BCL-XL in complex with inhibitor (Compound 3)==
-<StructureSection load='3zln' size='340' side='right' caption='[[3zln]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
+<StructureSection load='3zln' size='340' side='right'caption='[[3zln]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3zln]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZLN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3zln]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZLN FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H0Y:6-[(8E)-8-(1,3-BENZOTHIAZOL-2-YLHYDRAZINYLIDENE)-6,7-DIHYDRO-5H-NAPHTHALEN-2-YL]PYRIDINE-2-CARBOXYLIC+ACID'>H0Y</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.288&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zk6|3zk6]], [[3zlo|3zlo]], [[3zlr|3zlr]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H0Y:6-[(8E)-8-(1,3-BENZOTHIAZOL-2-YLHYDRAZINYLIDENE)-6,7-DIHYDRO-5H-NAPHTHALEN-2-YL]PYRIDINE-2-CARBOXYLIC+ACID'>H0Y</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zln OCA], [http://pdbe.org/3zln PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zln RCSB], [http://www.ebi.ac.uk/pdbsum/3zln PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zln ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zln OCA], [https://pdbe.org/3zln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zln RCSB], [https://www.ebi.ac.uk/pdbsum/3zln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zln ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>   Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
+[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>   Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 21: @@
 ==See Also==
-*[[B-cell lymphoma protein|B-cell lymphoma protein]]
+*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Colman, P M]]
+[[Category: Large Structures]]
-[[Category: Czabotar, P E]]
+[[Category: Colman PM]]
-[[Category: Lessene, G L]]
+[[Category: Czabotar PE]]
-[[Category: Smith, B J]]
+[[Category: Lessene GL]]
-[[Category: Apoptosis]]
+[[Category: Smith BJ]]
-[[Category: Inhibitor]]