3zip: Difference between revisions

<StructureSection load='3zip' size='340' side='right' caption='[[3zip]], [[Resolution|resolution]] 2.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[3zip]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZIP FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zin|3zin]], [[3zio|3zio]], [[3ziq|3ziq]], [[3zir|3zir]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zip OCA], [http://pdbe.org/3zip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zip RCSB], [http://www.ebi.ac.uk/pdbsum/3zip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zip ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/IMA2_MOUSE IMA2_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.  

*[[Importin|Importin]]

[[Category: Lk3 transgenic mice]]

[[Category: Synthetic construct sequences]]

[[Category: Chang, C W]]

[[Category: Counago, R M]]

[[Category: Kobe, B]]

[[Category: Williams, S J]]

[[Category: Transport protein]]