2ye3: Difference between revisions

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-[[Image:2ye3.png|left|200px]]
-<!--
+==HSP90 inhibitors and drugs from fragment and virtual screening==
-The line below this paragraph, containing "STRUCTURE_2ye3", creates the "Structure Box" on the page.
+<StructureSection load='2ye3' size='340' side='right'caption='[[2ye3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2ye3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YE3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VXX:METHYL+VANILLATE'>VXX</scene></td></tr>
-{{STRUCTURE_2ye3|  PDB=2ye3  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ye3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye3 OCA], [https://pdbe.org/2ye3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ye3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ye3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
-===HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING===
+==See Also==
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
+== References ==
-==About this Structure==
+<references/>
-[[2ye3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE3 OCA].
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:021561141</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Baker, L M.]]
+[[Category: Large Structures]]
-[[Category: Hubbard, R E.]]
+[[Category: Baker LM]]
-[[Category: Roughley, S D.]]
+[[Category: Hubbard RE]]
-[[Category: Atp-binding]]
+[[Category: Roughley SD]]
-[[Category: Atpase]]
-[[Category: Chaperone]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphoprotein]]
-[[Category: Phosphorylation]]
-[[Category: Pu3]]
-[[Category: Stress response]]