2y5k: Difference between revisions

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-[[Image:2y5k.png|left|200px]]
-<!--
+==Orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase==
-The line below this paragraph, containing "STRUCTURE_2y5k", creates the "Structure Box" on the page.
+<StructureSection load='2y5k' size='340' side='right'caption='[[2y5k]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2y5k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y5K FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YCU:1-[5-(2-METHOXYETHYL)-4-METHYL-THIOPHEN-2-YL]SULFONYL-3-[4-METHOXY-6-(METHYLCARBAMOYLAMINO)PYRIDIN-2-YL]UREA'>YCU</scene></td></tr>
-{{STRUCTURE_2y5k|  PDB=2y5k  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5k OCA], [https://pdbe.org/2y5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y5k RCSB], [https://www.ebi.ac.uk/pdbsum/2y5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y5k ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A novel sulfonylureido pyridine series exemplified by compound 19 yielded potent inhibitors of FBPase showing significant glucose reduction and modest glycogen lowering in the acute db/db mouse model for Type-2 diabetes. Our inhibitors occupy the allosteric binding site and also extend into the dyad interface region of tetrameric FBPase.
-===ORALLY ACTIVE AMINOPYRIDINES AS INHIBITORS OF TETRAMERIC FRUCTOSE 1,6-BISPHOSPHATASE===
+Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.,Hebeisen P, Haap W, Kuhn B, Mohr P, Wessel HP, Zutter U, Kirchner S, Ruf A, Benz J, Joseph C, Alvarez-Sanchez R, Gubler M, Schott B, Benardeau A, Tozzo E, Kitas E Bioorg Med Chem Lett. 2011 Jun 1;21(11):3237-42. Epub 2011 Apr 20. PMID:21550236<ref>PMID:21550236</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2y5k" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21550236}}, adds the Publication Abstract to the page
+*[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21550236 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21550236}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[2y5k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5K OCA].
-==Reference==
-<ref group="xtra">PMID:021550236</ref><references group="xtra"/>
-[[Category: Fructose-bisphosphatase]]
 [[Category: Homo sapiens]]
-[[Category: Alvarez-Sanchez, R.]]
+[[Category: Large Structures]]
-[[Category: Benardeau, A.]]
+[[Category: Alvarez-Sanchez R]]
-[[Category: Benz, J.]]
+[[Category: Benardeau A]]
-[[Category: Gubler, M.]]
+[[Category: Benz J]]
-[[Category: Haap, W.]]
+[[Category: Gubler M]]
-[[Category: Hebeisen, P.]]
+[[Category: Haap W]]
-[[Category: Joseph, C.]]
+[[Category: Hebeisen P]]
-[[Category: Kirchner, S.]]
+[[Category: Joseph C]]
-[[Category: Kitas, E.]]
+[[Category: Kirchner S]]
-[[Category: Kuhn, B.]]
+[[Category: Kitas E]]
-[[Category: Mohr, P.]]
+[[Category: Kuhn B]]
-[[Category: Ruf, A.]]
+[[Category: Mohr P]]
-[[Category: Schott, B.]]
+[[Category: Ruf A]]
-[[Category: Tozzo, E.]]
+[[Category: Schott B]]
-[[Category: Wessel, H P.]]
+[[Category: Tozzo E]]
-[[Category: Zutter, U.]]
+[[Category: Wessel HP]]
+[[Category: Zutter U]]