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==Crystal structure of Aplysia californica AChBP in complex with d- tubocurarine==
==Crystal structure of Aplysia californica AChBP in complex with d- tubocurarine==
<StructureSection load='2xyt' size='340' side='right' caption='[[2xyt]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='2xyt' size='340' side='right'caption='[[2xyt]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xyt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYT OCA]. <br>
<table><tr><td colspan='2'>[[2xyt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XYT FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TC9:D-TUBOCURARINE'>TC9</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wn9|2wn9]], [[2w8f|2w8f]], [[2byp|2byp]], [[2c9t|2c9t]], [[2byq|2byq]], [[2w8g|2w8g]], [[2x00|2x00]], [[2uz6|2uz6]], [[2wnl|2wnl]], [[2br7|2br7]], [[2br8|2br8]], [[2xnv|2xnv]], [[2byr|2byr]], [[2byn|2byn]], [[2bys|2bys]], [[2xnt|2xnt]], [[2wnj|2wnj]], [[2wzy|2wzy]], [[2wnc|2wnc]], [[2xnu|2xnu]], [[2xys|2xys]], [[2y7y|2y7y]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TC9:D-TUBOCURARINE'>TC9</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyt OCA], [https://pdbe.org/2xyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xyt RCSB], [https://www.ebi.ac.uk/pdbsum/2xyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xyt ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xyt RCSB], [http://www.ebi.ac.uk/pdbsum/2xyt PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors.,Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, Ulens C PLoS Biol. 2011 Mar;9(3):e1001034. Epub 2011 Mar 29. PMID:21468359<ref>PMID:21468359</ref>
A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors.,Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, Ulens C PLoS Biol. 2011 Mar;9(3):e1001034. Epub 2011 Mar 29. PMID:21468359<ref>PMID:21468359</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2xyt" style="background-color:#fffaf0;"></div>
==See Also==
*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
[[Category: Brams, M.]]
[[Category: Large Structures]]
[[Category: Elk, R Van.]]
[[Category: Brams M]]
[[Category: Krijnen, L.]]
[[Category: Krijnen L]]
[[Category: Kuzmin, D.]]
[[Category: Kuzmin D]]
[[Category: Pandya, A.]]
[[Category: Pandya A]]
[[Category: Smit, A B.]]
[[Category: Smit AB]]
[[Category: Tsetlin, V.]]
[[Category: Tsetlin V]]
[[Category: Ulens, C.]]
[[Category: Ulens C]]
[[Category: Yakel, J L.]]
[[Category: Yakel JL]]
[[Category: Amidation]]
[[Category: Van Elk R]]
[[Category: Conformational flexibility]]
[[Category: Conotoxin]]
[[Category: Neurotoxin nicotinic]]
[[Category: Postsynaptic neurotoxin]]
[[Category: Receptor]]
[[Category: Receptor-toxin complex]]

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