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==STRUCTURE OF THE BACILLUS SUBTILIS PROPHAGE DUTPASE WITH DUPNHPP==
 
<StructureSection load='2xy3' size='340' side='right' caption='[[2xy3]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
==Structure of the Bacillus subtilis prophage dUTPase with dUpNHpp==
<StructureSection load='2xy3' size='340' side='right'caption='[[2xy3]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xy3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XY3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xy3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XY3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y1t|2y1t]], [[2xx6|2xx6]], [[2baz|2baz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xy3 OCA], [https://pdbe.org/2xy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xy3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xy3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xy3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xy3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xy3 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YOSS_BACSU YOSS_BACSU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2xy3" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
*[[DUTPase 3D structures|DUTPase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: DUTP diphosphatase]]
[[Category: Large Structures]]
[[Category: Fogg, M J.]]
[[Category: Fogg MJ]]
[[Category: Garcia-Nafria, J.]]
[[Category: Garcia-Nafria J]]
[[Category: Harkiolaki, M.]]
[[Category: Harkiolaki M]]
[[Category: Persson, R.]]
[[Category: Persson R]]
[[Category: Wilson, K S.]]
[[Category: Wilson KS]]
[[Category: Hydrolase]]
[[Category: Phe-lid]]

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