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==CRYSTAL STRUCTURE OF IMPORTIN 13 - UBC9 COMPLEX==
==CRYSTAL STRUCTURE OF IMPORTIN 13 - UBC9 COMPLEX==
<StructureSection load='2xwu' size='340' side='right' caption='[[2xwu]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2xwu' size='340' side='right'caption='[[2xwu]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xwu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xwu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWU FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gro|2gro]], [[2grr|2grr]], [[1kps|1kps]], [[2grp|2grp]], [[1z5s|1z5s]], [[2x19|2x19]], [[2grq|2grq]], [[1a3s|1a3s]], [[2grn|2grn]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwu OCA], [https://pdbe.org/2xwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwu RCSB], [https://www.ebi.ac.uk/pdbsum/2xwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xwu RCSB], [http://www.ebi.ac.uk/pdbsum/2xwu PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBC9_HUMAN UBC9_HUMAN] Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation.<ref>PMID:8668529</ref> <ref>PMID:11451954</ref> <ref>PMID:15809060</ref> <ref>PMID:19744555</ref> <ref>PMID:19638400</ref> <ref>PMID:17466333</ref> <ref>PMID:20077568</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2xwu" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Importin|Importin]]
*[[Importin 3D structures|Importin 3D structures]]
*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
== References ==
== References ==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Large Structures]]
[[Category: Bono, F.]]
[[Category: Bono F]]
[[Category: Gruenwald, M.]]
[[Category: Gruenwald M]]
[[Category: Ligase-nuclear protein complex]]
[[Category: Nuclear import]]

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