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==Crystal structure of human uridine phosphorylase 2== | |||
<StructureSection load='2xrf' size='340' side='right'caption='[[2xrf]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
=== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xrf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr> | ||
[[2xrf]] is a 3 chain structure | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrf OCA], [https://pdbe.org/2xrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrf RCSB], [https://www.ebi.ac.uk/pdbsum/2xrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrf ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UPP2_HUMAN UPP2_HUMAN] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xr/2xrf_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xrf ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[ | *[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Berglund H]] | |||
[[Category: Berglund | [[Category: Bountra C]] | ||
[[Category: Bountra | [[Category: Collins R]] | ||
[[Category: Collins | [[Category: Edwards AM]] | ||
[[Category: Flodin S]] | |||
[[Category: Edwards | [[Category: Flores A]] | ||
[[Category: Flodin | [[Category: Graslund S]] | ||
[[Category: Flores | [[Category: Hammarstrom M]] | ||
[[Category: Graslund | [[Category: Johansson I]] | ||
[[Category: Hammarstrom | [[Category: Karlberg T]] | ||
[[Category: Johansson | [[Category: Kol S]] | ||
[[Category: Karlberg | [[Category: Kotenyova T]] | ||
[[Category: Kol | [[Category: Kouznetsova E]] | ||
[[Category: Kotenyova | [[Category: Moche M]] | ||
[[Category: Kouznetsova | [[Category: Nordlund P]] | ||
[[Category: Moche | [[Category: Nyman T]] | ||
[[Category: Nordlund | [[Category: Persson C]] | ||
[[Category: Nyman | [[Category: Schuler H]] | ||
[[Category: Persson | [[Category: Schutz P]] | ||
[[Category: Schuler | [[Category: Siponen MI]] | ||
[[Category: Schutz | [[Category: Thorsell AG]] | ||
[[Category: Siponen | [[Category: Tresaugues L]] | ||
[[Category: Thorsell | [[Category: Van Der Berg S]] | ||
[[Category: Tresaugues | [[Category: Wahlberg E]] | ||
[[Category: | [[Category: Weigelt J]] | ||
[[Category: | [[Category: Welin M]] | ||
[[Category: | |||
[[Category: | |||
Latest revision as of 13:37, 20 December 2023
Crystal structure of human uridine phosphorylase 2Crystal structure of human uridine phosphorylase 2
Structural highlights
FunctionUPP2_HUMAN Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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