2xp8: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 3: / Line 3: @@
 <StructureSection load='2xp8' size='340' side='right'caption='[[2xp8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xp8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XP8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XP8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xp8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XP8 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=4FY:4-(MORPHOLIN-4-YLCARBONYL)-2-PHENYL-1H-IMIDAZOLE-5-CARBOXYLIC+ACID'>4FY</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f8a|1f8a]], [[1i8g|1i8g]], [[1pin|1pin]], [[2xpb|2xpb]], [[2xp3|2xp3]], [[2xp5|2xp5]], [[1nmw|1nmw]], [[1zcn|1zcn]], [[2xp4|2xp4]], [[2f21|2f21]], [[2xp6|2xp6]], [[1nmv|1nmv]], [[2xp9|2xp9]], [[2xp7|2xp7]], [[1i8h|1i8h]], [[2xpa|2xpa]], [[1i6c|1i6c]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=4FY:4-(MORPHOLIN-4-YLCARBONYL)-2-PHENYL-1H-IMIDAZOLE-5-CARBOXYLIC+ACID'>4FY</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xp8 OCA], [https://pdbe.org/2xp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xp8 RCSB], [https://www.ebi.ac.uk/pdbsum/2xp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xp8 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xp8 OCA], [http://pdbe.org/2xp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xp8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xp8 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
+[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 27: / Line 26: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Peptidylprolyl isomerase]]
+[[Category: Baker L]]
-[[Category: Baker, L]]
+[[Category: Bryant CJ]]
-[[Category: Bryant, C J]]
+[[Category: Davis BE]]
-[[Category: Davis, B E]]
+[[Category: Dokurno P]]
-[[Category: Dokurno, P]]
+[[Category: Fromont C]]
-[[Category: Fromont, C]]
+[[Category: Matossova N]]
-[[Category: Matossova, N]]
+[[Category: Moore JD]]
-[[Category: Moore, J D]]
+[[Category: Murray JB]]
-[[Category: Murray, J B]]
+[[Category: Northfield CJ]]
-[[Category: Northfield, C J]]
+[[Category: Nunns C]]
-[[Category: Nunns, C]]
+[[Category: Oldfield V]]
-[[Category: Oldfield, V]]
+[[Category: Potter A]]
-[[Category: Potter, A]]
+[[Category: Ray S]]
-[[Category: Ray, S]]
+[[Category: Richardson CM]]
-[[Category: Richardson, C M]]
+[[Category: Robinson D]]
-[[Category: Robinson, D]]
+[[Category: Scrace SF]]
-[[Category: Scrace, S F]]
+[[Category: Surgenor AE]]
-[[Category: Surgenor, A E]]
-[[Category: Cell cycle]]
-[[Category: Isomerase]]
-[[Category: Oncogenic transformation]]
-[[Category: Proline directed kinase]]