2xk6: Difference between revisions

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-==STRUCTURE OF NEK2 BOUND TO AMINOPYRAZINE COMPOUND 36==
-<StructureSection load='2xk6' size='340' side='right' caption='[[2xk6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+==Structure of Nek2 bound to aminopyrazine compound 36==
+<StructureSection load='2xk6' size='340' side='right'caption='[[2xk6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XK6 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xk6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XK6 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EQH:CIS-4-[3-AMINO-6-(3-CYCLOPROPYLTHIOPHEN-2-YL)PYRAZIN-2-YL]CYCLOHEXANECARBOXYLIC+ACID'>EQH</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xkc|2xkc]], [[2w5b|2w5b]], [[2xnp|2xnp]], [[2xk8|2xk8]], [[2wqo|2wqo]], [[2xno|2xno]], [[2jav|2jav]], [[2xnn|2xnn]], [[2xk4|2xk4]], [[2xk3|2xk3]], [[2w5a|2w5a]], [[2xnm|2xnm]], [[2xke|2xke]], [[2xk7|2xk7]], [[2xkd|2xkd]], [[2w5h|2w5h]], [[2xkf|2xkf]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EQH:CIS-4-[3-AMINO-6-(3-CYCLOPROPYLTHIOPHEN-2-YL)PYRAZIN-2-YL]CYCLOHEXANECARBOXYLIC+ACID'>EQH</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xk6 OCA], [https://pdbe.org/2xk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xk6 RCSB], [https://www.ebi.ac.uk/pdbsum/2xk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xk6 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xk6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xk6 RCSB], [http://www.ebi.ac.uk/pdbsum/2xk6 PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NEK2_HUMAN NEK2_HUMAN] Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.<ref>PMID:11742531</ref> <ref>PMID:14978040</ref> <ref>PMID:12857871</ref> <ref>PMID:15358203</ref> <ref>PMID:15388344</ref> <ref>PMID:15161910</ref> <ref>PMID:17283141</ref> <ref>PMID:17621308</ref> <ref>PMID:17626005</ref> <ref>PMID:18086858</ref> <ref>PMID:18297113</ref> <ref>PMID:20034488</ref> <ref>PMID:21076410</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2xk6" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
 == References ==
 <references/>
@@ Line 24: / Line 27: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Large Structures]]
-[[Category: Bayliss, R]]
+[[Category: Bayliss R]]
-[[Category: Mas-Droux, C]]
+[[Category: Mas-Droux C]]
-[[Category: Centrosome]]
-[[Category: Mitosis]]
-[[Category: Transferase]]