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==THE STRUCTURE OF CYTOCHROME C PEROXIDASE COMPOUND I==
 
<StructureSection load='2xil' size='340' side='right' caption='[[2xil]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
==The structure of cytochrome c peroxidase Compound I==
<StructureSection load='2xil' size='340' side='right'caption='[[2xil]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xil]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XIL FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xil]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XIL FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cpg|1cpg]], [[1bva|1bva]], [[2v23|2v23]], [[3ccx|3ccx]], [[6ccp|6ccp]], [[1aeu|1aeu]], [[1dcc|1dcc]], [[1s6v|1s6v]], [[1bej|1bej]], [[1ml2|1ml2]], [[1ccl|1ccl]], [[1beq|1beq]], [[1aem|1aem]], [[1jci|1jci]], [[1u74|1u74]], [[2b10|2b10]], [[2pcc|2pcc]], [[1aeb|1aeb]], [[1cpd|1cpd]], [[1ccg|1ccg]], [[1cca|1cca]], [[1ac4|1ac4]], [[1cmu|1cmu]], [[1aeo|1aeo]], [[1bep|1bep]], [[1aet|1aet]], [[2pcb|2pcb]], [[1aeh|1aeh]], [[1aev|1aev]], [[1kxn|1kxn]], [[1aen|1aen]], [[1aeg|1aeg]], [[4ccp|4ccp]], [[5ccp|5ccp]], [[2cep|2cep]], [[2x07|2x07]], [[1cmp|1cmp]], [[1ryc|1ryc]], [[1cce|1cce]], [[2b0z|2b0z]], [[1bes|1bes]], [[1dsp|1dsp]], [[1z53|1z53]], [[2b12|2b12]], [[1bem|1bem]], [[1mkr|1mkr]], [[1sog|1sog]], [[1ccj|1ccj]], [[1aee|1aee]], [[1a2f|1a2f]], [[1cpe|1cpe]], [[1jdr|1jdr]], [[1dse|1dse]], [[1a2g|1a2g]], [[1aes|1aes]], [[1bek|1bek]], [[1zbz|1zbz]], [[1cck|1cck]], [[1mkq|1mkq]], [[1mk8|1mk8]], [[1ebe|1ebe]], [[1cci|1cci]], [[1krj|1krj]], [[2b11|2b11]], [[1aef|1aef]], [[1cyf|1cyf]], [[1aek|1aek]], [[1ccb|1ccb]], [[1u75|1u75]], [[1ac8|1ac8]], [[1dsg|1dsg]], [[1dj1|1dj1]], [[1dj5|1dj5]], [[2ccp|2ccp]], [[1cmt|1cmt]], [[1aeq|1aeq]], [[1aej|1aej]], [[1ds4|1ds4]], [[7ccp|7ccp]], [[1sdq|1sdq]], [[2x08|2x08]], [[2gb8|2gb8]], [[4ccx|4ccx]], [[1kxm|1kxm]], [[1kok|1kok]], [[1bj9|1bj9]], [[2bcn|2bcn]], [[1zby|1zby]], [[1ccp|1ccp]], [[2cyp|2cyp]], [[1dso|1dso]], [[1stq|1stq]], [[3ccp|3ccp]], [[2v2e|2v2e]], [[1aa4|1aa4]], [[1aed|1aed]], [[1ccc|1ccc]], [[1cmq|1cmq]], [[1cpf|1cpf]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-c_peroxidase Cytochrome-c peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xil OCA], [https://pdbe.org/2xil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xil RCSB], [https://www.ebi.ac.uk/pdbsum/2xil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xil ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xil OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xil RCSB], [http://www.ebi.ac.uk/pdbsum/2xil PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/CCPR_YEAST CCPR_YEAST] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xi/2xil_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xi/2xil_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xil ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2xil" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Cytochrome c peroxidase|Cytochrome c peroxidase]]
*[[Cytochrome c peroxidase 3D structures|Cytochrome c peroxidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cytochrome-c peroxidase]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Gumiero, A.]]
[[Category: Gumiero A]]
[[Category: Moody, P C.E.]]
[[Category: Moody PCE]]
[[Category: Raven, E L.]]
[[Category: Raven EL]]
[[Category: Apx]]
[[Category: Ascorbate peroxidase]]
[[Category: Compound iii]]
[[Category: Ferrous heme]]
[[Category: Ferryl ion]]
[[Category: Oxidoreductase]]

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