2xe7: Difference between revisions
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==The complete reaction cycle of human phosphoglycerate kinase: The open ternary complex with 3PG and ADP== | ==The complete reaction cycle of human phosphoglycerate kinase: The open ternary complex with 3PG and ADP== | ||
<StructureSection load='2xe7' size='340' side='right' caption='[[2xe7]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2xe7' size='340' side='right'caption='[[2xe7]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xe7]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2xe7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XE7 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xe7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xe7 OCA], [https://pdbe.org/2xe7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xe7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xe7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xe7 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[https://omim.org/entry/300653 300653]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 24: | Line 23: | ||
==See Also== | ==See Also== | ||
*[[Phosphoglycerate | *[[Phosphoglycerate kinase 3D structures|Phosphoglycerate kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Baxter | [[Category: Baxter NJ]] | ||
[[Category: Blackburn | [[Category: Blackburn GM]] | ||
[[Category: Bowler | [[Category: Bowler MW]] | ||
[[Category: Cliff | [[Category: Cliff MJ]] | ||
[[Category: Merli | [[Category: Merli A]] | ||
[[Category: Vas | [[Category: Vas M]] | ||
[[Category: Waltho | [[Category: Waltho JP]] | ||