2x8h: Difference between revisions

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==Thioredoxin glutathione reductase from Schistosoma mansoni in complex with GSH==
==Thioredoxin glutathione reductase from Schistosoma mansoni in complex with GSH==
<StructureSection load='2x8h' size='340' side='right' caption='[[2x8h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2x8h' size='340' side='right'caption='[[2x8h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8H FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x8g|2x8g]], [[2v6o|2v6o]], [[2x8c|2x8c]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8h OCA], [https://pdbe.org/2x8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8h RCSB], [https://www.ebi.ac.uk/pdbsum/2x8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8h OCA], [http://pdbe.org/2x8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x8h RCSB], [http://www.ebi.ac.uk/pdbsum/2x8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q962Y6_SCHMA Q962Y6_SCHMA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Blood fluke]]
[[Category: Large Structures]]
[[Category: Thioredoxin-disulfide reductase]]
[[Category: Schistosoma mansoni]]
[[Category: Angelucci, F]]
[[Category: Angelucci F]]
[[Category: Bellelli, A]]
[[Category: Bellelli A]]
[[Category: Boumis, G]]
[[Category: Boumis G]]
[[Category: Brunori, M]]
[[Category: Brunori M]]
[[Category: Dimastrogiovanni, D]]
[[Category: Dimastrogiovanni D]]
[[Category: Miele, A E]]
[[Category: Miele AE]]
[[Category: Saccoccia, F]]
[[Category: Saccoccia F]]
[[Category: Detoxification pathway]]
[[Category: Flavoprotein]]
[[Category: Nadph]]
[[Category: Oxidoreductase]]

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