2x6f: Difference between revisions

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-{{Seed}}
-[[Image:2x6f.jpg|left|200px]]
-<!--
+==THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE==
-The line below this paragraph, containing "STRUCTURE_2x6f", creates the "Structure Box" on the page.
+<StructureSection load='2x6f' size='340' side='right'caption='[[2x6f]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2x6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X6F FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3MA:6-AMINO-3-METHYLPURINE'>3MA</scene></td></tr>
-{{STRUCTURE_2x6f|  PDB=2x6f  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x6f OCA], [https://pdbe.org/2x6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x6f RCSB], [https://www.ebi.ac.uk/pdbsum/2x6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x6f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9W1M7_DROME Q9W1M7_DROME]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/2x6f_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x6f ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Phosphoinositide 3-kinases (PI3Ks) are lipid kinases with diverse roles in health and disease. The primordial PI3K, Vps34, is present in all eukaryotes and has essential roles in autophagy, membrane trafficking, and cell signaling. We solved the crystal structure of Vps34 at 2.9 angstrom resolution, which revealed a constricted adenine-binding pocket, suggesting the reason that specific inhibitors of this class of PI3K have proven elusive. Both the phosphoinositide-binding loop and the carboxyl-terminal helix of Vps34 mediate catalysis on membranes and suppress futile adenosine triphosphatase cycles. Vps34 appears to alternate between a closed cytosolic form and an open form on the membrane. Structures of Vps34 complexes with a series of inhibitors reveal the reason that an autophagy inhibitor preferentially inhibits Vps34 and underpin the development of new potent and specific Vps34 inhibitors.
-===THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE===
+Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34.,Miller S, Tavshanjian B, Oleksy A, Perisic O, Houseman BT, Shokat KM, Williams RL Science. 2010 Mar 26;327(5973):1638-42. PMID:20339072<ref>PMID:20339072</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2x6f" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20339072}}, adds the Publication Abstract to the page
+*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20339072 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20339072}}
+__TOC__
+</StructureSection>
-==About this Structure==
-X6F is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X6F OCA].
-==Reference==
-<ref group="xtra">PMID:20339072</ref><references group="xtra"/>
 [[Category: Drosophila melanogaster]]
-[[Category: Houseman, B T.]]
+[[Category: Large Structures]]
-[[Category: Miller, S.]]
+[[Category: Houseman BT]]
-[[Category: Oleksy, A.]]
+[[Category: Miller S]]
-[[Category: Perisic, O.]]
+[[Category: Oleksy A]]
-[[Category: Shokat, K M.]]
+[[Category: Perisic O]]
-[[Category: Tavshanjian, B.]]
+[[Category: Shokat KM]]
-[[Category: Williams, R L.]]
+[[Category: Tavshanjian B]]
-[[Category: 3-ma]]
+[[Category: Williams RL]]
-[[Category: 3ma]]
-[[Category: Autophagy]]
-[[Category: Phosphoinositide 3-kinase class iii]]
-[[Category: Pi3k class iii]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  7 10:40:15 2010''