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==Crystal Structure of the Mono-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa==
==Crystal Structure of the Mono-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa==
<StructureSection load='2wrs' size='340' side='right' caption='[[2wrs]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
<StructureSection load='2wrs' size='340' side='right'caption='[[2wrs]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wrs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRS FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wrs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WRS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2whg|2whg]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrs OCA], [https://pdbe.org/2wrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wrs RCSB], [https://www.ebi.ac.uk/pdbsum/2wrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wrs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrs OCA], [http://pdbe.org/2wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wrs RCSB], [http://www.ebi.ac.uk/pdbsum/2wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wrs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q70E11_PSEAI Q70E11_PSEAI]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wrs_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wrs_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Beta-lactamase|Beta-lactamase]]
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Large Structures]]
[[Category: Bebrone, C]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Dehareng, D]]
[[Category: Bebrone C]]
[[Category: Delbruck, H]]
[[Category: Dehareng D]]
[[Category: Ferrer, J L]]
[[Category: Delbruck H]]
[[Category: Frere, J M]]
[[Category: Ferrer J-L]]
[[Category: Galleni, M]]
[[Category: Frere J-M]]
[[Category: Gaumont, A C]]
[[Category: Galleni M]]
[[Category: Gulea, M]]
[[Category: Gaumont A-C]]
[[Category: Hamel, M]]
[[Category: Gulea M]]
[[Category: Hoffmann, K]]
[[Category: Hamel M]]
[[Category: Horsfall, L]]
[[Category: Hoffmann K]]
[[Category: Lassaux, P]]
[[Category: Horsfall L]]
[[Category: Mercuri, P S]]
[[Category: Lassaux P]]
[[Category: Traore, D A.K]]
[[Category: Mercuri PS]]
[[Category: Hydrolase]]
[[Category: Traore DAK]]

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