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==Average NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei==
==Average NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei==
<StructureSection load='2jol' size='340' side='right' caption='[[2jol]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2jol' size='340' side='right'caption='[[2jol]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2aic 2aic]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JOL FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jol]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2aic 2aic]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JOL FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r6e|1r6e]], [[1r9k|1r9k]], [[1gzs|1gzs]], [[2jok|2jok]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bopE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jol OCA], [https://pdbe.org/2jol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jol RCSB], [https://www.ebi.ac.uk/pdbsum/2jol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jol ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jol OCA], [http://pdbe.org/2jol PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jol RCSB], [http://www.ebi.ac.uk/pdbsum/2jol PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jol ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BOPE_BURPS BOPE_BURPS]] Activator for both CDC42 and RAC1 by directly interacting with these Rho GTPases and acting as a guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, thus promoting bacterial entry into non-phagocytic cells.<ref>PMID:12410823</ref> <ref>PMID:12897019</ref> <ref>PMID:15289563</ref>
[https://www.uniprot.org/uniprot/BOPE_BURPS BOPE_BURPS] Activator for both CDC42 and RAC1 by directly interacting with these Rho GTPases and acting as a guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, thus promoting bacterial entry into non-phagocytic cells.<ref>PMID:12410823</ref> <ref>PMID:12897019</ref> <ref>PMID:15289563</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus pseudomallei whitmore 1913]]
[[Category: Bagby, S]]
[[Category: Elsen, J M.H van den]]
[[Category: Galyov, E E]]
[[Category: Upadhyay, A]]
[[Category: Williams, C]]
[[Category: Wu, H]]
[[Category: Burkholderia pseudomallei]]
[[Category: Burkholderia pseudomallei]]
[[Category: Cell invasion]]
[[Category: Large Structures]]
[[Category: Guanine nucleotide exchange factor]]
[[Category: Bagby S]]
[[Category: Signaling protein]]
[[Category: Galyov EE]]
[[Category: Sope]]
[[Category: Upadhyay A]]
[[Category: Sope2]]
[[Category: Williams C]]
[[Category: Type iii secretion]]
[[Category: Wu H]]
[[Category: Van den Elsen JMH]]

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