2jnu: Difference between revisions

<StructureSection load='2jnu' size='340' side='right'caption='[[2jnu]]' scene=''>

<table><tr><td colspan='2'>[[2jnu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JNU FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnu OCA], [https://pdbe.org/2jnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jnu RCSB], [https://www.ebi.ac.uk/pdbsum/2jnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jnu ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/RGS14_HUMAN RGS14_HUMAN] Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory.<ref>PMID:15917656</ref> <ref>PMID:17635935</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/2jnu_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jnu ConSurf].

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith C]]

[[Category: Ball LJ]]

[[Category: Bray J]]

[[Category: Brockmann C]]

[[Category: Diehl A]]

[[Category: Dowler EF]]

[[Category: Doyle DA]]

[[Category: Edwards A]]

[[Category: Elkins J]]

[[Category: Gileadi C]]

[[Category: Higman VA]]

[[Category: Kuhne R]]

[[Category: Leidert M]]

[[Category: Oschkinat H]]

[[Category: Phillips C]]

[[Category: Rehbein K]]

[[Category: Schmieder P]]

[[Category: Schoch GA]]

[[Category: Soundararajan M]]

[[Category: Sundstrom M]]

[[Category: Weigelt J]]

[[Category: Yang X]]