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==Solution structure of the Bromodomain-containing protein 4 ET domain==
==Solution structure of the Bromodomain-containing protein 4 ET domain==
<StructureSection load='2jns' size='340' side='right' caption='[[2jns]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2jns' size='340' side='right'caption='[[2jns]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jns]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JNS FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jns]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JNS FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Brd4, Mcap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jns OCA], [http://pdbe.org/2jns PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jns RCSB], [http://www.ebi.ac.uk/pdbsum/2jns PDBsum], [http://www.topsan.org/Proteins/RSGI/2jns TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jns OCA], [https://pdbe.org/2jns PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jns RCSB], [https://www.ebi.ac.uk/pdbsum/2jns PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jns ProSAT], [https://www.topsan.org/Proteins/RSGI/2jns TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_MOUSE BRD4_MOUSE]] Plays a role in a process governing chromosomal dynamics during mitosis.<ref>PMID:10938129</ref>
[https://www.uniprot.org/uniprot/BRD4_MOUSE BRD4_MOUSE] Plays a role in a process governing chromosomal dynamics during mitosis.<ref>PMID:10938129</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/2jns_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/2jns_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jns ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Guntert, P]]
[[Category: Mus musculus]]
[[Category: Lin, Y J]]
[[Category: Guntert P]]
[[Category: Padmanabhan, B]]
[[Category: Lin YJ]]
[[Category: Structural genomic]]
[[Category: Padmanabhan B]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Bromodomain containing protein 4]]
[[Category: Et-domain]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Unknown function]]

Latest revision as of 13:08, 20 December 2023

Solution structure of the Bromodomain-containing protein 4 ET domainSolution structure of the Bromodomain-containing protein 4 ET domain

Structural highlights

2jns is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

BRD4_MOUSE Plays a role in a process governing chromosomal dynamics during mitosis.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Dey A, Ellenberg J, Farina A, Coleman AE, Maruyama T, Sciortino S, Lippincott-Schwartz J, Ozato K. A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol Cell Biol. 2000 Sep;20(17):6537-49. PMID:10938129
Drag the structure with the mouse to rotate

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