Telomerase 3D structures: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky

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-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} - For a general description of the protein see [[Telomerase]]
+==Telomerase 3D structures==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[3kyl]], [[3du5]], [[3du6]] – TERT+DNA – ''Tribolium castaneum''<br />
+*Telomerase reverse transcriptase
-[[2r4g]] – TtTERT RNA binding domain – ''Tetrahymena thermophila''<br />
-[[2b2a]] – TtTERT (mutant)<br />
+**[[5c9h]] – hTERT + RNA - human<br />
-[[2fey]] - TtTERC RNA P2b hairpin – NMR<br />
+**[[4mnq]] – hTERT + MHC + b-2-microglobulin + T cell receptor<br />
-[[1q75]], [[2k96]] – hTERC RNA P2b hairpin (mutant) – human – NMR<br />
+**[[5ugw]] – hTERT thumb domain<br />
-[[2k95]], [[1na2]] - hTERC RNA P2b hairpin – NMR<br />
+**[[7bg9]], [[7bgb]] – hTERT H/ACA RNP lobe – Cryo EM<br />
-[[2qh2]] - hTERC RNA CR7– NMR<br />
+**[[7qxa]] – hTERT + TPP1 + DNA – Cryo EM<br />
-[[1ymo]] - hTERC RNAstem loop IV– NMR<br />
+**[[7qxb]], [[7qxs]], [[7trd]], [[7tre]], [[7trf]] – hTERT + TPP1 + POT1 + DNA – Cryo EM<br />
-[[1z31]] - hTERC RNA Pj6 hairpin – NMR<br />
+**[[4lmo]] – TERT RNA binding domain - puffer<br />
+**[[4o26]] – TERT + telomerase TR – rice fish<br />
+**[[3du6]], [[3du5]] - rfbTERT catalytic subunit - red flour beetle<br />
+**[[5cqg]] - rfbTERT + inhibitor <br />
+**[[3kyl]], [[6e53]], [[6uso]], [[6usq]], [[6usp]] - rfbTERT + DNA<br />
+**[[7kqm]], [[7kqn]] - rfbTERT telomerase catalytic subunit + DNA + RNA<br />
+**[[6usr]] - rfbTERT + DNA + G2P<br />
+**[[2r4g]] - TtTERT telomerase catalytic subunit 1-1117 - ''Tetrahymena thermophila''<br />
+**[[2b2a]] - TtTERT telomerase catalytic subunit (mutant) <br />
+**[[7lma]], [[7lmb]] – TtTERT + telomerase-associated protein + RNA + DNA – Cryo EM<br />
+**[[7uy6]], [[7uy7]], [[8gap]] – TtTERT catalytic subunit + P50 + P65 + TEB1 + TEB2 + TEB3 + RNA + DNA – Cryo EM<br />
+**[[7uy5]] – TtTERT catalytic subunit + P50 + P65 + TEB1 + TEB2 + TEB3 + telomerase-associated protein + RNA + DNA – Cryo EM<br />
+**[[6d6v]] – TtTERT + telomerase-associated protein + TEB2 + RNA + DNA – Cryo EM<br />
+**[[5c9h]] - TtTERT catalytic subunit + DNA<br />
+**[[5lgf]] - OgTERT N-terminal - ''Ogataea polymorpha'' - NMR<br />
+**[[5npt]] – OgTERT N-terminal <br />
+**[[6zd1]], [[6zd2]], [[6zd6]] - CaTERT – ''Candida albicans''<br />
+**[[6zdp]], [[6zdq]], [[6zdu]] - CaTERT + RNA <br />
+**[[7sbe]] – KlTERT RNA-binding domain 171-404 - ''Kluyveromyces lactis'' <br />
-[[Category:Topic Page]]
+*Telomerase RNA
+**[[7trc]], [[7v99]], [[7v9a]] - hTERC in telomerase holoenzyme – Cryo EM<br />
+**[[1q75]], [[2k96]] – hTERC P2b hairpin (mutant) – human – NMR<br />
+**[[2k95]], [[1na2]] - hTERC P2b hairpin – NMR<br />
+**[[2l3e]] - hTERC P2a P2b hairpin – NMR<br />
+**[[2qh2]] - hTERC CR7– NMR<br />
+**[[1ymo]] - hTERC stem loop IV – NMR<br />
+**[[1z31]] - hTERC Pj6 hairpin – NMR<br />
+**[[2kye]] - hTERC P6.1 hairpin – NMR<br />
+**[[2qh3]], [[2qh4]] - hTERC terminal hairpin loop – NMR<br />
+**[[5kqe]] - TERC P2b hairpin – ''Oryzias latipes'' - NMR<br />
+**[[2fey]] - TtTERC P2b hairpin – NMR<br />
+**[[5kmz]] - TtTERC pseudoknot – NMR<br />
+**[[2m21]] - TtTERC stem loop IV – NMR<br />
+**[[2m22]] - TtTERC helix II – NMR<br />
+**[[2mhi]] - TERC CR4/5 – medaka - NMR<br />
+**[[2m8k]] - KlTERC pseudoknot - NMR<br />
+**[[8bh9]], [[8bh8]] - TERC + EST1 – ''Candida tropicalis''<br />
+}}
+[[Category:Topic Page]]
-[[Telomerase]] (TEL) adds DNA repeats to the tail end of telomeres.  It carries its own RNA.  The human TEL is composed of 2 [[Telomerase Reverse Transcriptase]] (TERT), 2 Telomerase RNA (TERC) and 2 dyskerin (DKC1) molecules.   For additional details see [[ Catalytic Subunit of T. Castaneum TERT Polymerase]].