Telomerase 3D structures: Difference between revisions

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[[Image:Tert.png|left|200px|thumb|Structure of the catalytic subunit of telomerase, TERT, [[3du5]]]]
==Telomerase 3D structures==
{{STRUCTURE_3du5|  PDB=3du5  | SIZE=300| SCENE=Telomerase/Cv/1 |right|CAPTION=Catalytic subunit of telomerase, TERT, [[3du5]] }}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


[[Telomerase]] (TEL) adds DNA repeats to the tail end of telomeres.  It carries its own RNA.  The human TEL is composed of 2 Telomerase Reverse Transcriptase (TERT), 2 Telomerase RNA (TERC) and 2 dyskerin (DKC1) molecules. The images at the left and at the right correspond to one representative Telomerase structure, ''i.e.'' crystal structure of catalytic subunit of telomerase, TERT, from ''Tribolium castaneum'' ([[3du5]]).
*Telomerase reverse transcriptase
**[[5c9h]] – hTERT + RNA - human<br />
**[[4mnq]] – hTERT + MHC + b-2-microglobulin + T cell receptor<br />
**[[5ugw]] – hTERT thumb domain<br />
**[[7bg9]], [[7bgb]] – hTERT H/ACA RNP lobe – Cryo EM<br />
**[[7qxa]] – hTERT + TPP1 + DNA – Cryo EM<br />
**[[7qxb]], [[7qxs]], [[7trd]], [[7tre]], [[7trf]] – hTERT + TPP1 + POT1 + DNA – Cryo EM<br />
**[[4lmo]] – TERT RNA binding domain - puffer<br />
**[[4o26]] – TERT + telomerase TR – rice fish<br />
**[[3du6]], [[3du5]] - rfbTERT catalytic subunit - red flour beetle<br />
**[[5cqg]] - rfbTERT + inhibitor <br />
**[[3kyl]], [[6e53]], [[6uso]], [[6usq]], [[6usp]] - rfbTERT + DNA<br />
**[[7kqm]], [[7kqn]] - rfbTERT telomerase catalytic subunit + DNA + RNA<br />
**[[6usr]] - rfbTERT + DNA + G2P<br />
**[[2r4g]] - TtTERT telomerase catalytic subunit 1-1117 - ''Tetrahymena thermophila''<br />
**[[2b2a]] - TtTERT telomerase catalytic subunit (mutant) <br />
**[[7lma]], [[7lmb]] – TtTERT + telomerase-associated protein + RNA + DNA – Cryo EM<br />
**[[7uy6]], [[7uy7]], [[8gap]] – TtTERT catalytic subunit + P50 + P65 + TEB1 + TEB2 + TEB3 + RNA + DNA – Cryo EM<br />
**[[7uy5]] – TtTERT catalytic subunit + P50 + P65 + TEB1 + TEB2 + TEB3 + telomerase-associated protein + RNA + DNA – Cryo EM<br />
**[[6d6v]] – TtTERT + telomerase-associated protein + TEB2 + RNA + DNA – Cryo EM<br />
**[[5c9h]] - TtTERT catalytic subunit + DNA<br />
**[[5lgf]] - OgTERT N-terminal - ''Ogataea polymorpha'' - NMR<br />
**[[5npt]] – OgTERT N-terminal <br />
**[[6zd1]], [[6zd2]], [[6zd6]] - CaTERT – ''Candida albicans''<br />
**[[6zdp]], [[6zdq]], [[6zdu]] - CaTERT + RNA <br />
**[[7sbe]] – KlTERT RNA-binding domain 171-404 - ''Kluyveromyces lactis'' <br />


{{TOC limit|limit=2}}
*Telomerase RNA


== 3D Structures of Telomerase ==
**[[7trc]], [[7v99]], [[7v9a]] - hTERC in telomerase holoenzyme – Cryo EM<br />
<br/>
**[[1q75]], [[2k96]] – hTERC P2b hairpin (mutant) – human – NMR<br />
[[3kyl]], [[3du5]], [[3du6]] – TERT+DNA – ''Tribolium castaneum''<br />
**[[2k95]], [[1na2]] - hTERC P2b hairpin – NMR<br />
[[2r4g]] – TtTERT RNA binding domain+RNA – ''Tetrahymena thermophila''<br />
**[[2l3e]] - hTERC P2a P2b hairpin – NMR<br />
[[2b2a]] – TtTERT (mutant)<br />
**[[2qh2]] - hTERC CR7– NMR<br />
**[[1ymo]] - hTERC stem loop IV – NMR<br />
**[[1z31]] - hTERC Pj6 hairpin – NMR<br />
**[[2kye]] - hTERC P6.1 hairpin – NMR<br />
**[[2qh3]], [[2qh4]] - hTERC terminal hairpin loop – NMR<br />
**[[5kqe]] - TERC P2b hairpin – ''Oryzias latipes'' - NMR<br />
**[[2fey]] - TtTERC P2b hairpin – NMR<br />
**[[5kmz]] - TtTERC pseudoknot – NMR<br />
**[[2m21]] - TtTERC stem loop IV – NMR<br />
**[[2m22]] - TtTERC helix II – NMR<br />
**[[2mhi]] - TERC CR4/5 – medaka - NMR<br />
**[[2m8k]] - KlTERC pseudoknot - NMR<br />
**[[8bh9]], [[8bh8]] - TERC + EST1 – ''Candida tropicalis''<br />
}}


[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 13:38, 14 December 2023

Telomerase 3D structuresTelomerase 3D structures

Updated on 14-December-2023

    • 5c9h – hTERT + RNA - human
    • 4mnq – hTERT + MHC + b-2-microglobulin + T cell receptor
    • 5ugw – hTERT thumb domain
    • 7bg9, 7bgb – hTERT H/ACA RNP lobe – Cryo EM
    • 7qxa – hTERT + TPP1 + DNA – Cryo EM
    • 7qxb, 7qxs, 7trd, 7tre, 7trf – hTERT + TPP1 + POT1 + DNA – Cryo EM
    • 4lmo – TERT RNA binding domain - puffer
    • 4o26 – TERT + telomerase TR – rice fish
    • 3du6, 3du5 - rfbTERT catalytic subunit - red flour beetle
    • 5cqg - rfbTERT + inhibitor
    • 3kyl, 6e53, 6uso, 6usq, 6usp - rfbTERT + DNA
    • 7kqm, 7kqn - rfbTERT telomerase catalytic subunit + DNA + RNA
    • 6usr - rfbTERT + DNA + G2P
    • 2r4g - TtTERT telomerase catalytic subunit 1-1117 - Tetrahymena thermophila
    • 2b2a - TtTERT telomerase catalytic subunit (mutant)
    • 7lma, 7lmb – TtTERT + telomerase-associated protein + RNA + DNA – Cryo EM
    • 7uy6, 7uy7, 8gap – TtTERT catalytic subunit + P50 + P65 + TEB1 + TEB2 + TEB3 + RNA + DNA – Cryo EM
    • 7uy5 – TtTERT catalytic subunit + P50 + P65 + TEB1 + TEB2 + TEB3 + telomerase-associated protein + RNA + DNA – Cryo EM
    • 6d6v – TtTERT + telomerase-associated protein + TEB2 + RNA + DNA – Cryo EM
    • 5c9h - TtTERT catalytic subunit + DNA
    • 5lgf - OgTERT N-terminal - Ogataea polymorpha - NMR
    • 5npt – OgTERT N-terminal
    • 6zd1, 6zd2, 6zd6 - CaTERT – Candida albicans
    • 6zdp, 6zdq, 6zdu - CaTERT + RNA
    • 7sbe – KlTERT RNA-binding domain 171-404 - Kluyveromyces lactis
  • Telomerase RNA
    • 7trc, 7v99, 7v9a - hTERC in telomerase holoenzyme – Cryo EM
    • 1q75, 2k96 – hTERC P2b hairpin (mutant) – human – NMR
    • 2k95, 1na2 - hTERC P2b hairpin – NMR
    • 2l3e - hTERC P2a P2b hairpin – NMR
    • 2qh2 - hTERC CR7– NMR
    • 1ymo - hTERC stem loop IV – NMR
    • 1z31 - hTERC Pj6 hairpin – NMR
    • 2kye - hTERC P6.1 hairpin – NMR
    • 2qh3, 2qh4 - hTERC terminal hairpin loop – NMR
    • 5kqe - TERC P2b hairpin – Oryzias latipes - NMR
    • 2fey - TtTERC P2b hairpin – NMR
    • 5kmz - TtTERC pseudoknot – NMR
    • 2m21 - TtTERC stem loop IV – NMR
    • 2m22 - TtTERC helix II – NMR
    • 2mhi - TERC CR4/5 – medaka - NMR
    • 2m8k - KlTERC pseudoknot - NMR
    • 8bh9, 8bh8 - TERC + EST1 – Candida tropicalis

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky
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