5oix: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5oix is ON HOLD
+==Structure of the HMPV P oligomerization domain at 1.6 A==
+<StructureSection load='5oix' size='340' side='right'caption='[[5oix]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5oix]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OIX FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oix OCA], [https://pdbe.org/5oix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oix RCSB], [https://www.ebi.ac.uk/pdbsum/5oix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oix ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q91KZ5_9MONO Q91KZ5_9MONO]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The phosphoprotein (P) is the main and essential cofactor of the RNA polymerase (L) of non-segmented, negative-strand RNA viruses. P positions the viral polymerase onto its nucleoprotein-RNA template and acts as a chaperone of the nucleoprotein (N), thereby preventing nonspecific encapsidation of cellular RNAs. The phosphoprotein of human metapneumovirus (HMPV) forms homotetramers composed of a stable oligomerization domain (Pcore) flanked by large intrinsically disordered regions (IDRs). Here we combined x-ray crystallography of Pcore with small angle x-ray scattering (SAXS)-based ensemble modeling of the full-length P protein and several of its fragments to provide a structural description of P that captures its dynamic character, and highlights the presence of varyingly stable structural elements within the IDRs. We discuss the implications of the structural properties of HMPV P for the assembly and functioning of the viral transcription/replication machinery.
-Authors: Renner, M., Paesen, G.C., Grison, C.M., Granier, S., Grimes, J.M., Leyrat, C.
+Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering.,Renner M, Paesen GC, Grison CM, Granier S, Grimes JM, Leyrat C Sci Rep. 2017 Nov 1;7(1):14865. doi: 10.1038/s41598-017-14448-z. PMID:29093501<ref>PMID:29093501</ref>
-Description: Structure of the HMPV P oligomerization domain at 1.6 A
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Renner, M]]
+<div class="pdbe-citations 5oix" style="background-color:#fffaf0;"></div>
-[[Category: Leyrat, C]]
+== References ==
-[[Category: Paesen, G.C]]
+<references/>
-[[Category: Grimes, J.M]]
+__TOC__
-[[Category: Grison, C.M]]
+</StructureSection>
-[[Category: Granier, S]]
+[[Category: Human metapneumovirus]]
+[[Category: Large Structures]]
+[[Category: Granier S]]
+[[Category: Grimes JM]]
+[[Category: Grison CM]]
+[[Category: Leyrat C]]
+[[Category: Paesen GC]]
+[[Category: Renner M]]