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==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Chloro-4-fluorobenzamide==
==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Chloro-4-fluorobenzamide==
<StructureSection load='5ofw' size='340' side='right' caption='[[5ofw]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='5ofw' size='340' side='right'caption='[[5ofw]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ofw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OFW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OFW FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ofw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OFW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9TW:3-chloranyl-4-fluoranyl-benzamide'>9TW</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PHGDH, PGDH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9TW:3-chloranyl-4-fluoranyl-benzamide'>9TW</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ofw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ofw OCA], [http://pdbe.org/5ofw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ofw RCSB], [http://www.ebi.ac.uk/pdbsum/5ofw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ofw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ofw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ofw OCA], [https://pdbe.org/5ofw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ofw RCSB], [https://www.ebi.ac.uk/pdbsum/5ofw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ofw ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.  
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
== Function ==
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Basle, A]]
[[Category: Large Structures]]
[[Category: Blackburn, T J]]
[[Category: Basle A]]
[[Category: Cano, C]]
[[Category: Blackburn TJ]]
[[Category: Curtin, N J]]
[[Category: Cano C]]
[[Category: Noble, M E.M]]
[[Category: Curtin NJ]]
[[Category: Tucker, J]]
[[Category: Noble MEM]]
[[Category: Unterlass, J E]]
[[Category: Tucker J]]
[[Category: Dehydrogenase]]
[[Category: Unterlass JE]]
[[Category: Fbdd]]
[[Category: Oxidoreductase]]
[[Category: Serine metabolism]]

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