5ofw: Difference between revisions
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==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Chloro-4-fluorobenzamide== | ==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Chloro-4-fluorobenzamide== | ||
<StructureSection load='5ofw' size='340' side='right' caption='[[5ofw]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='5ofw' size='340' side='right'caption='[[5ofw]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ofw]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5ofw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OFW FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9TW:3-chloranyl-4-fluoranyl-benzamide'>9TW</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ofw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ofw OCA], [https://pdbe.org/5ofw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ofw RCSB], [https://www.ebi.ac.uk/pdbsum/5ofw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ofw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Basle | [[Category: Large Structures]] | ||
[[Category: Blackburn | [[Category: Basle A]] | ||
[[Category: Cano | [[Category: Blackburn TJ]] | ||
[[Category: Curtin | [[Category: Cano C]] | ||
[[Category: Noble | [[Category: Curtin NJ]] | ||
[[Category: Tucker | [[Category: Noble MEM]] | ||
[[Category: Unterlass | [[Category: Tucker J]] | ||
[[Category: Unterlass JE]] | |||