2g9p: Difference between revisions

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==NMR structure of a novel antimicrobial peptide, latarcin 2a, from spider (Lachesana tarabaevi) venom==
==NMR structure of a novel antimicrobial peptide, latarcin 2a, from spider (Lachesana tarabaevi) venom==
<StructureSection load='2g9p' size='340' side='right' caption='[[2g9p]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2g9p' size='340' side='right'caption='[[2g9p]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2g9p]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9P FirstGlance]. <br>
<table><tr><td colspan='2'>[[2g9p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lachesana_tarabaevi Lachesana tarabaevi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9P FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g9p RCSB], [http://www.ebi.ac.uk/pdbsum/2g9p PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9p OCA], [https://pdbe.org/2g9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9p RCSB], [https://www.ebi.ac.uk/pdbsum/2g9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LAT2A_LACTA LAT2A_LACTA] It has antimicrobial activity against Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=0.7 ug/ml), and B.subtilis VKM B-501 (MIC=0.4 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=1.0 ug/ml), E.coli MH1 (MIC=0.7 ug/ml), and P.aeruginosa PAO1 (MIC=6.7 ug/ml)), and yeasts (P.pastoris GS115 (MIC=6.7 ug/ml), and S.cerevisiae Y190 (MIC=54 ug/ml)). Also has a strong hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.<ref>PMID:16735513</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2g9p" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arseniev, A S.]]
[[Category: Lachesana tarabaevi]]
[[Category: Chupin, V V.]]
[[Category: Large Structures]]
[[Category: Dubovskii, P V.]]
[[Category: Arseniev AS]]
[[Category: Efremov, R G.]]
[[Category: Chupin VV]]
[[Category: Polyansky, A A.]]
[[Category: Dubovskii PV]]
[[Category: Volynsky, P E.]]
[[Category: Efremov RG]]
[[Category: Antimicrobial protein]]
[[Category: Polyansky AA]]
[[Category: Helix-hinge-helix]]
[[Category: Volynsky PE]]

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