2g9p: Difference between revisions
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==NMR structure of a novel antimicrobial peptide, latarcin 2a, from spider (Lachesana tarabaevi) venom== | ==NMR structure of a novel antimicrobial peptide, latarcin 2a, from spider (Lachesana tarabaevi) venom== | ||
<StructureSection load='2g9p' size='340' side='right' caption='[[2g9p | <StructureSection load='2g9p' size='340' side='right'caption='[[2g9p]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2g9p]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9P OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[2g9p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lachesana_tarabaevi Lachesana tarabaevi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9P FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9p OCA], [https://pdbe.org/2g9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9p RCSB], [https://www.ebi.ac.uk/pdbsum/2g9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9p ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/LAT2A_LACTA LAT2A_LACTA] It has antimicrobial activity against Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=0.7 ug/ml), and B.subtilis VKM B-501 (MIC=0.4 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=1.0 ug/ml), E.coli MH1 (MIC=0.7 ug/ml), and P.aeruginosa PAO1 (MIC=6.7 ug/ml)), and yeasts (P.pastoris GS115 (MIC=6.7 ug/ml), and S.cerevisiae Y190 (MIC=54 ug/ml)). Also has a strong hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.<ref>PMID:16735513</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2g9p" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Lachesana tarabaevi]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arseniev AS]] | ||
[[Category: | [[Category: Chupin VV]] | ||
[[Category: | [[Category: Dubovskii PV]] | ||
[[Category: | [[Category: Efremov RG]] | ||
[[Category: | [[Category: Polyansky AA]] | ||
[[Category: | [[Category: Volynsky PE]] |