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==Solution structure of the first C2H2 type zinc finger domain of Zinc finger protein 278==
==Solution structure of the first C2H2 type zinc finger domain of Zinc finger protein 278==
<StructureSection load='2epp' size='340' side='right' caption='[[2epp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2epp' size='340' side='right'caption='[[2epp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2epp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EPP FirstGlance]. <br>
<table><tr><td colspan='2'>[[2epp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EPP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PATZ1, PATZ, RIAZ, ZBTB19, ZNF278, ZSG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2epp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2epp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2epp RCSB], [http://www.ebi.ac.uk/pdbsum/2epp PDBsum], [http://www.topsan.org/Proteins/RSGI/2epp TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2epp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2epp OCA], [https://pdbe.org/2epp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2epp RCSB], [https://www.ebi.ac.uk/pdbsum/2epp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2epp ProSAT], [https://www.topsan.org/Proteins/RSGI/2epp TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/PATZ1_HUMAN PATZ1_HUMAN]] Note=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.  
[https://www.uniprot.org/uniprot/PATZ1_HUMAN PATZ1_HUMAN] Note=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PATZ1_HUMAN PATZ1_HUMAN]] Transcriptional repressor.<ref>PMID:10713105</ref>
[https://www.uniprot.org/uniprot/PATZ1_HUMAN PATZ1_HUMAN] Transcriptional repressor.<ref>PMID:10713105</ref>  
 
==See Also==
*[[Zinc Fingers|Zinc Fingers]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Inoue, M]]
[[Category: Large Structures]]
[[Category: Kigawa, T]]
[[Category: Inoue M]]
[[Category: Muto, Y]]
[[Category: Kigawa T]]
[[Category: Structural genomic]]
[[Category: Muto Y]]
[[Category: Shirouzu, M]]
[[Category: Shirouzu M]]
[[Category: Suzuki, S]]
[[Category: Suzuki S]]
[[Category: Tanabe, W]]
[[Category: Tanabe W]]
[[Category: Terada, T]]
[[Category: Terada T]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: C2h2]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Transcription]]
[[Category: Zinc finger domain]]

Latest revision as of 19:35, 13 December 2023

Solution structure of the first C2H2 type zinc finger domain of Zinc finger protein 278Solution structure of the first C2H2 type zinc finger domain of Zinc finger protein 278

Structural highlights

2epp is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Disease

PATZ1_HUMAN Note=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.

Function

PATZ1_HUMAN Transcriptional repressor.[1]

References

  1. ↑ Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F, Vollono E, Day PM, Santoro M, Lania L, Bruni CB, Fusco A, Chiariotti L. A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor. J Biol Chem. 2000 Mar 17;275(11):7894-901. PMID:10713105
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