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==Solution structure of FHV B2, a viral suppressor of RNAi==
==Solution structure of FHV B2, a viral suppressor of RNAi==
<StructureSection load='2b9z' size='340' side='right' caption='[[2b9z]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2b9z' size='340' side='right'caption='[[2b9z]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2b9z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Fhv Fhv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B9Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[2b9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B9Z FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 FHV])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9z OCA], [http://pdbe.org/2b9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b9z RCSB], [http://www.ebi.ac.uk/pdbsum/2b9z PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9z OCA], [https://pdbe.org/2b9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b9z RCSB], [https://www.ebi.ac.uk/pdbsum/2b9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b9z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/B2_FHV B2_FHV]] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:14745017</ref> <ref>PMID:16228003</ref>
[https://www.uniprot.org/uniprot/B2_FHV B2_FHV] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:14745017</ref> <ref>PMID:16228003</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 20:


==See Also==
==See Also==
*[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]]
*[[Flock house virus protein B2|Flock house virus protein B2]]
*[[P19|P19]]
*[[P19|P19]]
*[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
*[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
*[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]]
*[[User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing|User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing]]
*[[User:Wayne Decatur/Suppression of RNA Silencing by Viruses|User:Wayne Decatur/Suppression of RNA Silencing by Viruses]]
*[[User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing|User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fhv]]
[[Category: Flock House virus]]
[[Category: Izaurralde, E]]
[[Category: Large Structures]]
[[Category: Lingel, A]]
[[Category: Izaurralde E]]
[[Category: Sattler, M]]
[[Category: Lingel A]]
[[Category: Simon, B]]
[[Category: Sattler M]]
[[Category: All alpha-helical]]
[[Category: Simon B]]
[[Category: Symmetric antiparallel homodimer]]
[[Category: Viral protein]]

Latest revision as of 19:33, 13 December 2023

Solution structure of FHV B2, a viral suppressor of RNAiSolution structure of FHV B2, a viral suppressor of RNAi

Structural highlights

2b9z is a 2 chain structure with sequence from Flock House virus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

B2_FHV Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.[1] [2]

Publication Abstract from PubMed

We report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms an elongated binding interface with double-stranded RNA (dsRNA). This implies a novel mode of dsRNA recognition and provides insights into the mechanism of RNAi suppression by B2.

The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.,Lingel A, Simon B, Izaurralde E, Sattler M EMBO Rep. 2005 Dec;6(12):1149-55. PMID:16270100[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Li WX, Li H, Lu R, Li F, Dus M, Atkinson P, Brydon EW, Johnson KL, Garcia-Sastre A, Ball LA, Palese P, Ding SW. Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1350-5. Epub 2004 Jan 26. PMID:14745017 doi:http://dx.doi.org/10.1073/pnas.0308308100
  2. ↑ Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR. Dual modes of RNA-silencing suppression by Flock House virus protein B2. Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:16228003 doi:10.1038/nsmb1005
  3. ↑ Lingel A, Simon B, Izaurralde E, Sattler M. The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. EMBO Rep. 2005 Dec;6(12):1149-55. PMID:16270100
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