2b9z: Difference between revisions

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-[[Image:2b9z.png|left|200px]]
-{{STRUCTURE_2b9z|  PDB=2b9z  |  SCENE=  }}
+==Solution structure of FHV B2, a viral suppressor of RNAi==
+<StructureSection load='2b9z' size='340' side='right'caption='[[2b9z]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2b9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B9Z FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9z OCA], [https://pdbe.org/2b9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b9z RCSB], [https://www.ebi.ac.uk/pdbsum/2b9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b9z ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/B2_FHV B2_FHV] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:14745017</ref> <ref>PMID:16228003</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms an elongated binding interface with double-stranded RNA (dsRNA). This implies a novel mode of dsRNA recognition and provides insights into the mechanism of RNAi suppression by B2.
-===Solution structure of FHV B2, a viral suppressor of RNAi===
+The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.,Lingel A, Simon B, Izaurralde E, Sattler M EMBO Rep. 2005 Dec;6(12):1149-55. PMID:16270100<ref>PMID:16270100</ref>
-{{ABSTRACT_PUBMED_16270100}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2b9z" style="background-color:#fffaf0;"></div>
-[[2b9z]] is a 2 chain structure of [[Flock house virus B2 protein Suppression of RNA Silencing]], [[Plant Viral Protein p19 Suppression of RNA Silencing]], [[Suppression of RNA Silencing by Viruses]] and [[Tomato aspermy virus protein 2b Suppression of RNA Silencing]] with sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9Z OCA].
 ==See Also==
-*[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]]
+*[[Flock house virus protein B2|Flock house virus protein B2]]
-*[[Plant Viral Protein p19 Suppression of RNA Silencing|Plant Viral Protein p19 Suppression of RNA Silencing]]
+*[[P19|P19]]
 *[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
 *[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:016270100</ref><ref group="xtra">PMID:018040042</ref><references group="xtra"/>
+__TOC__
-[[Category: Flock house virus]]
+</StructureSection>
-[[Category: Izaurralde, E.]]
+[[Category: Flock House virus]]
-[[Category: Lingel, A.]]
+[[Category: Large Structures]]
-[[Category: Sattler, M.]]
+[[Category: Izaurralde E]]
-[[Category: Simon, B.]]
+[[Category: Lingel A]]
-[[Category: All alpha-helical]]
+[[Category: Sattler M]]
-[[Category: Symmetric antiparallel homodimer]]
+[[Category: Simon B]]
-[[Category: Viral protein]]