2wi3: Difference between revisions

 

==Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone==

<StructureSection load='2wi3' size='340' side='right'caption='[[2wi3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[2wi3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WI3 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZZ3:4-METHYL-6-(METHYLSULFANYL)-1,3,5-TRIAZIN-2-AMINE'>ZZ3</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wi3 OCA], [https://pdbe.org/2wi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wi3 RCSB], [https://www.ebi.ac.uk/pdbsum/2wi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wi3 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wi3_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wi3 ConSurf].

*[[Heat Shock Protein structures|Heat Shock Protein structures]]

[[Category: Barril X]]

[[Category: Borgognoni J]]

[[Category: Brough PA]]

[[Category: Chene P]]

[[Category: Davies NGM]]

[[Category: Davis B]]

[[Category: Drysdale MJ]]

[[Category: Dymock B]]

[[Category: Eccles SA]]

[[Category: Fromont C]]

[[Category: Garcia-Echeverria C]]

[[Category: Hayes A]]

[[Category: Hubbard RE]]

[[Category: Jordan AM]]

[[Category: Massey A]]

[[Category: Merret A]]

[[Category: Padfield A]]

[[Category: Parsons R]]

[[Category: Radimerski T]]

[[Category: Raynaud FI]]

[[Category: Robertson A]]

[[Category: Roughley SD]]

[[Category: Rugaard-Jensen M]]

[[Category: Schoepfer J]]

[[Category: Simmonite H]]

[[Category: Surgenor A]]

[[Category: Valenti M]]

[[Category: Walls S]]

[[Category: Webb P]]

[[Category: Wood M]]

[[Category: Workman P]]

[[Category: Wright LM]]