2wgp: Difference between revisions

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-{{Seed}}
-[[Image:2wgp.jpg|left|200px]]
-<!--
+==Crystal structure of human dual specificity phosphatase 14==
-The line below this paragraph, containing "STRUCTURE_2wgp", creates the "Structure Box" on the page.
+<StructureSection load='2wgp' size='340' side='right'caption='[[2wgp]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2wgp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGP FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-{{STRUCTURE_2wgp|  PDB=2wgp  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgp OCA], [https://pdbe.org/2wgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgp RCSB], [https://www.ebi.ac.uk/pdbsum/2wgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DUS14_HUMAN DUS14_HUMAN] Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wgp ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Dual-specificity phosphatases (DUSPs) are enzymes that participate in the regulation of biological processes such as cell growth, differentiation, transcription and metabolism. A number of DUSPs are able to dephosphorylate phosphorylated serine, threonine and tyrosine residues on mitogen-activated protein kinases (MAPKs) and thus are also classified as MAPK phosphatases (MKPs). As an increasing number of DUSPs are being identified and characterized, there is a growing need to understand their biological activities at the molecular level. There is also significant interest in identifying DUSPs that could be potential targets for drugs that modulate MAPK-dependent signaling and immune responses, which have been implicated in a variety of maladies including cancer, infectious diseases and inflammatory disorders. Here, the overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported. This structural information should accelerate the study of DUSP14 at the molecular level and may also accelerate the discovery and development of novel therapeutic agents.
-===CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITY PHOSPHATASE 14===
+Overproduction, purification and structure determination of human dual-specificity phosphatase 14.,Lountos GT, Tropea JE, Cherry S, Waugh DS Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1013-20. Epub 2009, Sep 16. PMID:19770498<ref>PMID:19770498</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2wgp" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_19770498}}, adds the Publication Abstract to the page
+*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 19770498 is the PubMed ID number.
+*[[MAP kinase phosphatase|MAP kinase phosphatase]]
--->
+== References ==
-{{ABSTRACT_PUBMED_19770498}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-WGP is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGP OCA].
-==Reference==
-<ref group="xtra">PMID:19770498</ref><ref group="xtra">PMID:11123293</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Cherry, S.]]
+[[Category: Large Structures]]
-[[Category: Lountos, G T.]]
+[[Category: Cherry S]]
-[[Category: Tropea, J E.]]
+[[Category: Lountos GT]]
-[[Category: Waugh, D S.]]
+[[Category: Tropea JE]]
-[[Category: Dual specificity phosphatase]]
+[[Category: Waugh DS]]
-[[Category: Dusp14]]
-[[Category: Hydrolase]]
-[[Category: Mkp6]]
-[[Category: Protein phosphatase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  7 13:58:54 2009''