2wef: Difference between revisions

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==Human 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1) in complex with AMP, PO4 and Magnesium==
The line below this paragraph, containing "STRUCTURE_2wef", creates the "Structure Box" on the page.
<StructureSection load='2wef' size='340' side='right'caption='[[2wef]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2wef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEF FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_2wef|  PDB=2wef  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wef OCA], [https://pdbe.org/2wef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wef RCSB], [https://www.ebi.ac.uk/pdbsum/2wef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wef ProSAT]</span></td></tr>
 
</table>
===HUMAN 3'(2'), 5'-BISPHOSPHATE NUCLEOTIDASE 1 (BPNT1) IN COMPLEX WITH AMP, PO4 AND MAGNESIUM===
== Function ==
 
[https://www.uniprot.org/uniprot/BPNT1_HUMAN BPNT1_HUMAN] Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.<ref>PMID:10224133</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2WEF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEF OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wef_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wef ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Berg, S Van Den.]]
[[Category: Arrowsmith CH]]
[[Category: Berglund, H.]]
[[Category: Berglund H]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Collins, R.]]
[[Category: Collins R]]
[[Category: Dahlgren, L G.]]
[[Category: Dahlgren LG]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Flodin, S.]]
[[Category: Flodin S]]
[[Category: Flores, A.]]
[[Category: Flores A]]
[[Category: Graslund, S.]]
[[Category: Graslund S]]
[[Category: Hammarstrom, M.]]
[[Category: Hammarstrom M]]
[[Category: Johansson, A.]]
[[Category: Johansson A]]
[[Category: Johansson, I.]]
[[Category: Johansson I]]
[[Category: Karlberg, T.]]
[[Category: Karlberg T]]
[[Category: Kotenyova, T.]]
[[Category: Kotenyova T]]
[[Category: Moche, M.]]
[[Category: Moche M]]
[[Category: Nilsson, M E.]]
[[Category: Nilsson ME]]
[[Category: Nordlund, P.]]
[[Category: Nordlund P]]
[[Category: Nyman, T.]]
[[Category: Nyman T]]
[[Category: Persson, C.]]
[[Category: Persson C]]
[[Category: Sagemark, J.]]
[[Category: Sagemark J]]
[[Category: Schueler, H.]]
[[Category: Schueler H]]
[[Category: Schutz, P.]]
[[Category: Schutz P]]
[[Category: Sgc, Structural Genomics Consortium.]]
[[Category: Siponen MI]]
[[Category: Siponen, M I.]]
[[Category: Thorsell AG]]
[[Category: Thorsell, A G.]]
[[Category: Tresaugues L]]
[[Category: Tresaugues, L.]]
[[Category: Van Der Berg S]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Welin, M.]]
[[Category: Welin M]]
[[Category: Wisniewska, M.]]
[[Category: Wisniewska M]]
[[Category: Hydrolase]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Sulfur metabolism]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 10:24:17 2009''

Latest revision as of 18:53, 13 December 2023

Human 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1) in complex with AMP, PO4 and MagnesiumHuman 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1) in complex with AMP, PO4 and Magnesium

Structural highlights

2wef is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BPNT1_HUMAN Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Spiegelberg BD, Xiong JP, Smith JJ, Gu RF, York JD. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. J Biol Chem. 1999 May 7;274(19):13619-28. PMID:10224133 doi:10.1074/jbc.274.19.13619

2wef, resolution 1.80Å

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