2wc4: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:2wc4.jpg|left|200px]]
-<!--
+==Structure of family 1 beta-glucosidase from Thermotoga maritima in complex with 3-imino-2-thia-(+)-castanospermine==
-The line below this paragraph, containing "STRUCTURE_2wc4", creates the "Structure Box" on the page.
+<StructureSection load='2wc4' size='340' side='right'caption='[[2wc4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2wc4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WC4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMF:(3Z,5S,6R,7S,8R,8AS)-3-(OCTYLIMINO)HEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRIDINE-5,6,7,8-TETROL'>AMF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-{{STRUCTURE_2wc4|  PDB=2wc4  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wc4 OCA], [https://pdbe.org/2wc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wc4 RCSB], [https://www.ebi.ac.uk/pdbsum/2wc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wc4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BGLA_THEMA BGLA_THEMA]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/2wc4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wc4 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Synthesis of a panel of iso(thio)urea-type ring-modified castanospermine analogues bearing a freely mutarotating pseudoanomeric hydroxyl group results in tight-binding beta-glucosidase inhibitors with unusual binding signatures; the presence of an N-octyl substituent imparts a remarkable anomeric selectivity, promoting strong binding of the appropriate beta-anomer by the beta-glucosidase.
-===STRUCTURE OF FAMILY 1 BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH 3-IMINO-2-THIA-(+)-CASTANOSPERMINE===
+Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring.,Aguilar-Moncayo M, Gloster TM, Turkenburg JP, Garcia-Moreno MI, Ortiz Mellet C, Davies GJ, Garcia Fernandez JM Org Biomol Chem. 2009 Jul 7;7(13):2738-47. Epub 2009 May 22. PMID:19532990<ref>PMID:19532990</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2wc4" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-WC4 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WC4 OCA].
+*[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]]
-[[Category: Beta-glucosidase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Thermotoga maritima]]
-[[Category: Aguilar, M.]]
+[[Category: Aguilar M]]
-[[Category: Davies, G J.]]
+[[Category: Davies GJ]]
-[[Category: Fernandez, J M.Garcia.]]
+[[Category: Garcia Fernandez JM]]
-[[Category: Garcia-Moreno, M I.]]
+[[Category: Garcia-Moreno MI]]
-[[Category: Gloster, T M.]]
+[[Category: Gloster TM]]
-[[Category: Mellet, C Ortiz.]]
+[[Category: Ortiz Mellet C]]
-[[Category: Turkenburg, J P.]]
+[[Category: Turkenburg JP]]
-[[Category: Carbohydrate metabolism]]
-[[Category: Castanospermine]]
-[[Category: Cellulose degradation]]
-[[Category: Family 1]]
-[[Category: Glycosidase]]
-[[Category: Glycoside hydrolase]]
-[[Category: Hydrolase]]
-[[Category: Inhibitor]]
-[[Category: Polysaccharide degradation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 10:22:43 2009''